Welcome
Welcome
Welcome to looong.ai. A website dedicated to living longer, healthier lives. Let me start out by saying that I am an idiot that has no background in science, health or any of the subjects that are present on this website. I do however, have a passion for healthy living. And I can do some programming. I’ve consumed hours and hours of podcasts in the health and longevity space and.. I tend to forget. A LOT. What was that dosage on Vitamin D3 again? And what’s the deal with airplane peanuts? looong.ai summarizes the many hours of content out there on YouTube to create a searchable database of easily digestible bits and pieces. Perfect for future reference!
- 338 hours of video analyzed
- 186 videos in our database
Analyzed content
Trending Topics
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Nutrition 2681
- 00:49 role of dietary intake of both carbohydrate and fats and the relationship…
- 01:33 a therapeutic carbohydrate restricted diet brings down so many cardiovascular risk biomarkers…
- 00:07:53 we opened the clinic as a carbohydrate restricted clinic
- 00:10:00 dr hallberg told them to eat a lot of fat and not…
- 15:40 right now we're at the tail end of our five-year data collection…
- 00:28:16 we've done a number of shows that have dealt with fatty acids…
- 00:34:04 if we have a high saturated fatty acid content within the vldl,…
- 00:34:44 this is one of my favorites um by dr brittany volk that…
- 00:35:19 they did a run in with a very low carbohydrate diet for…
- 00:41:32 high carbohydrate low carbohydrate low fat here on the left to a…
- 00:42:10 these were both that wanted the calorie intake of the two studies…
- 00:44:57 what we see here when we look at total saturated fatty acids…
- 00:46:01 the group that was randomized to the very low carbohydrate diet their…
- 00:40:18 today with the modernization and the amount of sugar everywhere that you…
- 76:02 when i'm writing about nutrition and chronic disease obesity diabetes the question…
- 01:30:17 you have a cohort of people say the nurses health study the…
- 108:00 researchers have just reported they're reporting on the first results on the…
- 01:52:42 evidence that maybe he understands nutrition and diet far better than I…
- 01:53:09 he took credit not just for getting Americans to eat less salt…
- 01:56:19 when we told people to go on low-fat diets in 1984 we…
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Exercise 1832
- 68:42 my practice also focuses so much on the role of glucose disposal…
- 01:19:14 exercise like crazy competed in you know half marathons triathlons olympic distance
- 02:25:26 she still exercises although not doing the things i used to
- 00:00 if you don't exercise if you don't make sure that your heart…
- 00:27:07 we have to do some exercise some hierarchic exercise to make sure…
- 28:14 so exercise is the number one thing you have to to to…
- 29:30 if you don't exercise you're gonna get small vessel disease I mean…
- 00:83:03 it's never too late to start exercising and there have been studies…
- 00:00 More vigorous intensity exercise, higher-intensity exercise can potentiate or lead to greater…
- 00:12 So some people engage in training and it's very frustrating because their…
- 00:33 Now some of that non-response was eliminated in a group that was…
- 05:27 So in short, I think you can do more vigorous or high-intensity…
- 07:25 It's determined by many physiological factors and processes, but it reflects the…
- 10:07 So if you're a serious or an elite or very high-level endurance…
- 11:12 And I think there that ratio can change fairly substantially. And you…
- 00:14:30 But you do, going hard, you mentioned intensity, high intensity interval training,…
- 00:15:07 220 minus your age is still probably the most common. There's a…
- 00:16:56 So bottom line is measuring it directly on yourself is always going…
- 00:18:22 World Fitness Calculator is, it's a valid calculator for estimating VO2 max.
- 21:08 But where you basically are performing a couple of levels of submaximal…
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Disease prevention 872
- 01:33 a therapeutic carbohydrate restricted diet brings down so many cardiovascular risk biomarkers…
- 17:47 we're looking at people who had insulin resistance long enough that their…
- 01:16:07 this insulin that you're going to inject to you okay and i'm…
- 01:22:21 i have never smoked
- 01:22:32 probably between 12 to 14 percent of people who get lung cancer…
- 01:26:29 non-smoking lung cancer is growing at scary rates it's being diagnosed and…
- 00:96:59 you know basically a patient of ours who has another physician uh…
- 01:40:57 i got to get this primary tumor out you know i'm considered…
- 01:43:08 can we improve your prognosis and maybe that doesn't mean you live…
- 01:51:53 you have a much greater chance of surviving cancer if you are…
- 02:05:11 i had no disease then after that radiation none and so i…
- 02:05:33 and started gemsar and you know everybody had said all these terrible…
- 02:17:08 a cancer diagnosis is so high up there i would have to…
- 02:23:45 cancer and yay life is great
- 13:36 what we do in life and talk about when you're talking about…
- 106:08 now the lung cancer effect is huge, that's like a six sigma…
- 01:03 you're gonna turn uh you know the Easter prone to go to…
- 07:43 we can predict future cognitivity tract so the people having more leakiness…
- 10:48 we have screened people by the major genetic risk factor for Alzheimer's…
- 09:22 we know that having vascular dysfunction will promote also um the formation…
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Substances 821
- 00:56:43 this uh kind of vicious cycle where omega-3 may play a major…
- 01:24:50 if you're a chronic Drinker of alcohol you tend you you will…
- 01:25:37 moderate drinking is up is impacting your brain function but not only…
- 01:27:01 chronic drinking is uh is uh of course people will have a…
- 01:28:16 red wine are full of polyphenols that you know from The Grapes…
- 00:34:55 I do have some scientific resources on my website my fitness comm…
- 00:60:46 did you tell them not to drink because alcohol has such a…
- 01:01:13 if I had a magic wand I would ask that people either…
- 00:96:53 the moment you said lowering cortisol thought of the two supplements that…
- 00:97:26 riola is very effective it's been shown in multiple randomized trials to…
- 00:98:54 phosphatidylserine PS for short fish oil also more modestly reduces cortisol
- 00:99:45 ashwagandha at least the time that I wrote that book ashwagandha's data…
- 13:41 metformin is a drug that has been used for many years uh…
- 25:32 enter metformin first line drug so most of the drugs so every…
- 00:28:01 so clearly metformin has this side effect initially which is a little…
- 73:48 the ITP was the first study that really put rapamycin on the…
- 74:13 when the ITP studied metformin it did not succeed
- 01:19:32 what I read was that berberine Poor Man's metformin could buffer blood…
- 01:20:18 one thing I noticed was that if I took berberine and I…
- 01:21:09 a carbos is another glucose disposal agent that actually found a survival…
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Sleep 612
- 00:57:54 reducing sedentary behavior is really important as well, as is proper sleep.
- 00:51:34 well sleep is primary for you right exactly um I always assumed…
- 01:01:24 it certainly disrupts patterns of nighttime sleep in particular my understanding that…
- 01:31:01 I would say sleep... you'd like to see people get enough sleep…
- 03:45 Helix sleep makes customized mattresses to give you the best possible night's…
- 24:52 sleep deprivation has a profound impact on insulin resistance
- 01:31:06 when you take a sleep supplement you can look at your eight…
- 01:49:37 what about sleep we hear so much these days about the importance…
- 01:50:24 there are definitive changes in sleep architecture we're seeing that in around…
- 01:47:59 how to optimize your sleep
- 00:51:00 for me uh for whatever reason you know gave me great sleep…
- 56:04 any of the growth hormone releasing peptides anytime you're going to make…
- 60:40 the critical need for us to get adequate amounts of quality sleep…
- 01:19:04 I took mk677 at bedtime and it was an hour later I…
- 01:25:28 never before have I found something that can improve the amount of…
- 01:26:42 pinealon is a remarkable way to increase rapid eye movement sleep
- 01:27:31 epitalon also um it's involved in DNA repair and might has been…
- 01:30:01 pinealon has been incredible and here's what's really interesting about it to…
- 01:31:07 I really like glycine as an inhibitory neurotransmitter. It's calming to the…
- 05:46 getting a great night's sleep is the foundation of mental health, physical…
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Metabolic health 564
- 00:08:06 people's diabetes was like going away, they were having normal blood sugar…
- 00:20:59 88 of Americans are not in optimal metabolic health.
- 00:22:00 They have normal fasting glucose and that's defined as less than 100.
- 00:22:08 They have normal triglycerides which are being defined as less than 150.
- 00:22:19 They have normal HDL cholesterol which for men is defined as greater…
- 00:26:55 it doesn't really matter if your trigs are up or down and…
- 00:29:51 when we have incorporation of saturated fatty acids into our triglycerides, that…
- 00:33:35 this process of de novo lipogenesis the conduit from fat being made…
- 48:29 because we do associate low fat with an increase in triglycerides but…
- 49:01 so palmitoleic or we like to call it poa is a product…
- 51:33 so if your triglycerides are really high again what's happening very likely…
- 00:58:14 it is increasing a process of lipogenesis it is making more lipid…
- 00:59:06 obesity is a protective mechanism
- 01:00:34 we want to know what an individual's carbohydrate tolerance is
- 64:34 patients will show up and nobody's ringing the bell until their hemoglobin…
- 64:53 measuring palmitoleic acid is one of them, that's exactly the kind of…
- 01:09:45 we know very low levels of carbohydrate restriction can reverse the disease…
- 01:11:39 the majority of people can reverse their disease, get normal glycemia, get…
- 01:12:42 the fact that people were on the incredibly high dose of insulin,…
- 01:31:02 mobilization deposition goes into fat goes on constantly like even when you're…
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Genetics 431
- 89:21 we're talking the genomics of cancer but for EGFR cancer there was…
- 01:31:58 it turns out i had a genetic mutation that didn't allow the…
- 00:14:17 screening people by ApoE genotype so if you have the genetic risk…
- 00:35:35 this is the sporadic form of small vessel disease but there is…
- 00:20:18 humans that have a single nucleotide polymorphism in the heat shock protein…
- 18:18 it was uh coffee mate red meat and cigarettes and they lived…
- 01:44:14 I was told that one in 12 people are heterozygous, one mutant…
- 00:41:15 they did a second analysis in parallel with discordant twins so same-sex…
- 30:07 I've actually got one ApoE4 allele, so I'm very interested in ApoE…
- 32:01 So when they measured the serum level of ApoE it turned out…
- 33:01 I'd be happy to show you the paper because that's... Yeah, that's…
- 34:12 The 4/4 was really viewed as, 'Boy, you're guaranteed to have an…
- 35:28 Between 65% and 80% of all the Alzheimer's cases, so... The majority…
- 00:32 C. elegans is a tiny one-millimeter-sized roundworm. It's found in rotting fruit,…
- 18:18 It could be and it'd be interesting to look at their aging…
- 20:38 we've sort of evolved in different regions across the globe and there's…
- 36:33 I think we also want to investigate why compounds do not work…
- 00:24 I think it says what it says based on the projection of…
- 00:36:20 So one of the main enzymes that repairs damage as we age,…
- 00:36:42 I completely agree, and so there are two major theories right now…
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Mental health 359
- 01:47:17 i now was bald and i was definitely fell into a deep…
- 01:49:49 crying never i've cried on a lot of planes since this diagnosis
- 02:21:10 originally it was actually hard to be around my kids when i…
- 08:51 i was depressed
- 09:16 i've suffered mild depressions my whole life
- 23:14 there was a friend of mine published a randomized control trial where…
- 00:32:28 I think this sauna is helps them adapt to that because of…
- 00:48:50 so women experience more trauma than men this is well established if…
- 01:42:55 A flat pattern where it's in the morning and it's high at…
- 02:30:38 knowing your a score is so essential in terms of a baseline…
- 10:54 recently I've been doing some dream exploration I've had some absolutely transformative…
- 133:58 the lower dose may be as effective simply on the basis of…
- 134:29 your brain is a prediction making machine it's a data interpretation machine…
- 05:42 there are thousands of quality peer-reviewed studies that emphasize how useful mindfulness…
- 06:23 Therapy is an extremely important component to overall health in fact I…
- 01:58:54 what was so exciting about this talk to me anyway was that…
- 01:40:57 there are some data showing that positive thoughts can enhance immune system…
- 01:41:16 no good has ever come from a negative thought
- 11:03 I'd like to take a quick break and acknowledge our sponsor better…
- 11:22 therapy is an extremely important component to one's overall health in fact…
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Hormone balance 323
- 01:37:54 the obese people kind of not making this up got fat because…
- 02:20:20 you lesion the vmh of the rat the rat gets obese and…
- 02:36:34 if your hypothesis is that fat accumulation dysregulated fat accumulation leads to…
- 02:29:56 first thing that have first observable effect from the bmh lesion is…
- 00:13 Dr Sarah gotfried is an obstetrician gynecologist who did her undergraduate training…
- 08:53 I think it's essential that you understand what your grandmother went through,…
- 00:13:35 the main sex hormones in a young woman who's in her teenage…
- 00:17:36 in your 20s that's when you want to do some base casing…
- 18:52 this Tango between estrogen and progesterone is incredibly important you want to…
- 24:29 addition to the levels of these hormones and if I'm forced to…
- 69:29 I'm now clear on the fact that a woman in her late…
- 72:27 cysts on the ovaries having um clinical manifestations of hyperandrogenism so that…
- 75:26 PCOS is not just a problem in terms of irregular periods and…
- 01:19:17 PCOS which is hyper androgenization of the ovary in there we're talking…
- 01:35:56 I went to the lab and I ran a hormone panel and…
- 01:42:29 I need a phosph Serene in the morning for people who are…
- 01:43:58 It maps to autoimmunity, it maps to fibromyalgia.
- 01:54:31 birth control is basically tonic estrogen so constantly taking estrogen estrogen women…
- 02:00:43 it's a progestin so it's not the normal uh progesterone that your…
- 02:02:09 the oral contraceptive depletes certain micronutrients so magnesium there's certain vitamin BS…
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Body weight 272
- 63:39 what do i really know about the science and what it really…
- 01:18:55 eaten well i've kept my weight in a normal weight even nine…
- 01:58:46 the atkins diet not only did people lose more weight, but their…
- 01:31:54 we've demonstrated that obesity is caused by energy balance imbalance
- 02:24:42 such that it's going to store excess fat it might not be…
- 02:44:50 failure to prevent obesity, failure to treat obesity, the obesity and diabetes…
- 15:23 many people who are carrying excess body fat don't feel good they…
- 17:16 beyond the weight loss you know we're seeing cognitive benefits we're seeing…
- 72:50 why do people have such trouble losing weight I would argue that…
- 01:12:02 you meet this woman and she's too heavy weight can be lost
- 01:12:53 a carbos led to weight loss or a lack of weight gain…
- 01:01:18 virtually all captive animals are obese relative to their wild cousins
- 01:04:57 we want our control animals to be at what we consider to…
- 93:14 take somebody that's on borderline overweight reduce them to a healthy body…
- 06:16 are you under-muscled or adequately muscled
- 00:55:28 this depending on the change in lean body mass yeah this is…
- 00:56:45 the exercise driven weight loss group did not experience a reduction in…
- 00:57:20 we know if you go on cr you're going to lose weight
- 00:58:55 what are the risks associated with significant caloric restriction in people as…
- 01:00:46 the cr animals the calorically restricted animals were fed 25 of what…
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Stress management 246
- 02:22:45 i haven't become as big a cancer advocate yet and i'm working…
- 00:41:14 fasting activates those stress response pathways I just mentioned that are meant…
- 55:07 I think for those of us who've got issues with autonomic balance…
- 56:20 I'm not a fan of lowering stress I'm a fan of lowering…
- 01:02:18 I think that stress you know people's I think people are starting…
- 67:25 so stress that is what you're really talking about is systemic stress…
- 01:18:51 you mentioned some of the psychosocial stress issues based on at the…
- 01:31:59 too much perceived stress
- 01:41:20 Placebo effects are real, we know this belief effects are not a…
- 01:42:32 you take a different group of people and randomly assign them to…
- 05:42 there are thousands of quality peer-reviewed studies that emphasize how useful mindfulness…
- 01:29:56 I do warn people that if they suffer from anxiety or they're…
- 01:59:05 if we're looking at having issues with sleeping and that anxiety provoked…
- 01:15:59 I look for every opportunity to surrender and it is that surrender…
- 41:35 next time you're stressed ask yourself is it a tragedy or an…
- 00:56:40 I think it's sad that people think life has to be stressful…
- 01:01:35 If you're not sleeping what is the reason for that and if…
- 01:07:23 my lab at Stanford ran a study on particular patterns of breathing…
- 01:12:16 I knew that was going to make me nervous so what I…
- 02:01:00 now you know stress there are some people who think they're stressed…
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Toxin exposure 201
- 23:46 there's certain heavy metals that are excreted better through sweat then through…
- 00:12:08 it's been moving younger and we think some of that is related…
- 00:34:29 I've had lots of people talking about the you know websites or…
- 01:31:41 the other advantage of glycine is it works on Phase 2 liver…
- 01:32:33 talk about glyphosate or round up same exact thing so many chemicals…
- 02:15:28 we're not talking about all the toxicities we just look at Roundup…
- 01:17:01 function provides over 100 Advanced lab tests that give you a key…
- 01:49:53 the pases or forever chemicals like Teflon have been linked to major…
- 13:34 study found that broccoli sprouts when administered as a Majin ate had…
- 14:14 the anti benzene brothy sprout drink worked some magic on over the…
- 14:51 another study showed that a tobacco specific lung carcinogen called nnk can…
- 24:07 when something bad gets in our system the body doesn't know it's…
- 24:07 what sorts of things well toxins bacteria viruses when something bad gets…
- 02:53:14 environmental exposures to various various kinds of chemicals uh tens of thousands…
- 00:72:41 they've also recently added tests for toxins such as BPA exposure from…
- 01:08:28 why not try and avoid volatile organic compounds in my house and…
- 01:08:41 why not put myself in natural fibers and try not to both…
- 21:15 And those are long, persisting heavy metals. If you get cadmium from…
- 66:42 they're still bathing their cellular biology in the toxic soup
- 74:35 I don't think the industry is standardized enough to be sure that…
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Gut health 187
- 20:14 we have over 700 different bacteria that leads in a perfect symbiotic…
- 00:42:34 doing a prolonged fast can basically cause organs to shrink inside of…
- 01:22 We discussed the gut microbiome which many people have heard about but…
- 19:31 the estrobolome is the set of microbes in and their DNA their…
- 27:56 what I try to get them to do is to have a…
- 00:31:39 our gut is very important it's populated by gut microbiota that communicate…
- 00:33:38 almost every player I've tested has increased intestinal permeability they just have…
- 00:34:17 there's a particular probiotic that is helpful in athletes with leaky gut…
- 36:27 Diversity of the microbiome is good, we hear this but no one's…
- 44:38 if you are a woman who has constipation, fatigue, maybe an autoimmune…
- 45:47 constipation is far more common in women and it signals a general…
- 00:48:20 okay instead of looking at constipation as a constellation of symptoms what…
- 00:49:46 constipation and that need to like control and restrain and hold things…
- 54:06 older women who come in who haven't had a bowel movement in…
- 54:22 my definition of constipation as a western mostly White girl is that…
- 02:24:01 I usually start with goova because they've got a good co-pay system…
- 01:38:33 you're also getting a better serotonin production from the gut because we…
- 23:47 BPC157 is a gut peptide so we don't have to worry about…
- 24:11 Oral BPC is more effective there for conditions like Crohn's or ulcerative…
- 00:42:49 ag1 also has probiotics and prebiotics that support a healthy gut microbiome
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Oral hygiene 147
- 00:29 i have a lot of pleasure talking about oral health with mds…
- 00:58 i think it's actually a very under-appreciated part of health um i…
- 01:47 i had my dental degree in brazil and then i had my…
- 05:29 you have 32 teeth in your mouth uh all of them of…
- 06:52 the first thing that jumps out to me is that there's a…
- 07:33 it's a very complex structure and it's for the reason so the…
- 08:20 the heart of the truth is actually the pope so it's high…
- 13:14 so technically you have the incisors so you have four of them…
- 15:13 so it's a much more complex because they're much more strong and…
- 16:09 the occlusion needs to be perfect because then you're going to hurt…
- 19:34 it's actually oral hygiene uh if you brush your teeth you're gonna…
- 20:55 for some reason you don't stop brushing or you start taking medication…
- 22:13 children uh when i did my studies with the twins and then…
- 00:26:55 the children that did not floss we saw elevated levels of gingival…
- 00:27:10 what was most striking was all those periodontal bacteria they just uh…
- 00:29:12 if you stop brushing which is the primary cause that uh your…
- 00:33:29 that leads to a rapid overgrowth of the uh the carry causing…
- 00:33:57 the cardiogenic bacteria they love sugar they metabolize the sugars that actually…
- 00:34:50 when they metabolize sugar they secrete acids and that acid is the…
- 00:37:52 they have like a stick that they use and they clean their…
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Circadian rhythm 138
- 00:38:19 Insulin sensitivity, blood glucose levels, all those things were measured and they…
- 07:51 if we talk about intermittent fasting that's where you have like the…
- 11:39 how much better would you be if you were to actually pay…
- 12:29 it's coming back to the chronobiology of we need to eat when…
- 01:58:56 people think that they don't want any cortisol and they think that…
- 73:32 I saw everybody getting very anxious their circadian rhythms disrupted
- 00:85:25 there's evidence that it's not only about how big the window is…
- 01:51:38 I joked that I'll be going into the grave and they'll be…
- 01:42 So, sleep is a circadian rhythm, and what a circadian rhythm is…
- 02:06 The timing of these rhythms are dependent on basically this system in…
- 02:18 And so, then, we have what are called clock cells within every…
- 02:49 Over 15% of the human encoding genome is regulated by the circadian…
- 03:43 We spend 90% of our time indoors. Two-hundred years ago, 90% of…
- 04:05 And because of that strange lighting environment, instead of having this waxing…
- 06:55 So it is the perception of light by the eye which is…
- 07:00 And then melatonin, we think of that as a sleepiness hormone, but…
- 07:15 And so it's telling all the clocks within the suprachiasmatic nucleus, Yeah,…
- 08:04 But back to the melatonin, the functions, it's a hormone, and it…
- 14:00 There's bacteria in our gut are also on a circadian rhythm.
- 00:27:38 Because we are getting too much light at night, it is telling…
Trending Substances
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Protein 148
- 25:03 you just need 15 gram of protein to really help and be…
- 27:27 women who are in their reproductive years need around 35 grams of…
- 00:32:33 women should probably ingest at least some protein high quality protein and…
- 70:23 there will be phases of the menstrual cycle where women will be…
- 02:19:25 in terms of nutrition you mentioned women should shoot for 1.1 1.2…
- 17:11 The conceptual way to do it, at least the way I do…
- 08:30 So, one is decreasing carbohydrate intake. So, that would lead to a…
- 00:32 right now I'm mostly optimized around energy balance which you know stay…
- 02:27:05 Most of my conscious effort around my diet goes into making sure…
- 00:23:39 you really need to be constantly giving yourself protein to not pull…
- 00:07 Protein is fundamental to our metabolism, insulin sensitivity, and the prevention of…
- 00:32 You'll discover how protein intake coupled with resistance training drives muscle repair…
- 00:58 We will critically examine current protein recommendations, challenging the adequacy of the…
- 01:11 Higher intakes ranging from 1.2 to 1.6 grams per kilogram are more…
- 02:08 Distributing protein evenly across meals can maximize muscle protein synthesis.
- 03:35 A meta-analysis from Dr. Stuart Phillips and colleagues highlights the importance of…
- 07:18 when older adults exercise before protein intake their muscle anabolic response is…
- 07:43 the most effective way to combat anabolic resistance as we age is…
- 09:36 the optimal range for daily protein intake is closer to 1.2 to…
- 10:09 older adults consuming at least 1.2 grams of protein per kilogram body…
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Metformin 113
- 00:26 Peter is going to discuss a paper on Metformin which is a…
- 13:41 metformin is a drug that has been used for many years uh…
- 00:16:31 the net effect of that is that it changes the ratio of…
- 00:16:45 what it unambiguously does is reduces the amount of glucose that the…
- 25:32 enter metformin first line drug so most of the drugs so every…
- 00:28:01 so clearly metformin has this side effect initially which is a little…
- 00:28:16 what I was thinking is hey this is going to help you…
- 00:33:00 the banister study found a very interesting result which was the crude…
- 00:34:53 the people who took metformin and had diabetes had a 15 one…
- 00:40:00 the tame trial which is an important trial is going to try…
- 48:39 When you adjust for age a very important check to do is…
- 00:52:39 you have two lines you have those that were on Metformin with…
- 00:53:23 the people who are taking metformin that have diabetes are dying at…
- 01:03:36 the people on Metformin had a 48 greater chance of dying in…
- 01:06:13 if you do the twin study which you could argue is a…
- 01:09:02 the keys paper makes it undeniably clear that in that population there…
- 74:13 when the ITP studied metformin it did not succeed
- 65:28 I have clearly seen the effect of a drug like metformin at…
- 95:18 berberine is kind of a poor man's metformin.
- 01:38 the two drugs i get asked about more than all other drugs…
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sugar 105
- 00:33:29 that leads to a rapid overgrowth of the uh the carry causing…
- 00:33:57 the cardiogenic bacteria they love sugar they metabolize the sugars that actually…
- 00:34:50 when they metabolize sugar they secrete acids and that acid is the…
- 00:40:18 today with the modernization and the amount of sugar everywhere that you…
- 68:36 in bethesda it was basically like a whole foods pescetarian diet right…
- 72:51 when you get 28 and a half percent of your calories from…
- 21:50 because the cancer loves sugar, and loves amino acids, right, and depends…
- 23:07 once the amino acids are low, the growth factors and the sugar…
- 09:39 CCK is stimulated by fatty acids, amino acids and particular amino acids…
- 00:57:12 fixed the diabetes so they become metabolically healthy eating high amounts of…
- 13:01 So no sugar, no high fructose corn syrup, other source of fructose.…
- 00:22:59 farmers are paid only to mostly to pay these these um corn…
- 12:48 it's a quote unquote healthy restaurant we tend to eat about 300…
- 00:46:41 Sugar probably short circuits our satiety mechanisms, leads to overgrowth of bacteria…
- 30:27 no sugar or cream i'm assuming thank you no sugar no cream…
- 00:12:15 this kind of dietary program that was high in phytochemicals but was…
- 00:14:14 It's removing a lot of the foods that are driving inflammation, ultraprocessed…
- 30:46 if we eat diets that are gene regulatory and they put our…
- 02:42 it's sustainable to the degree that they're willing to adopt a whole…
- 35:09 the problem for people trying to lose weight if they're eating salted…
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Glucose 99
- 00:39:53 reduced brain glucose metabolism can be measured up to decades even before…
- 00:44:01 exercise is therapeutic in the treatment of high blood sugar or diabetes,…
- 80:35 But I wouldn't have known that without that continuous, you know, data.…
- 00:31:00 he's tracked his glucose and Insulin going back 20 years so he…
- 01:22:10 the thread we haven't talked about with PCOS is the the role…
- 01:25:03 Continuous glucose monitors are the hugest, most gigantic fan of CGMs. I've…
- 01:35:56 I went to the lab and I ran a hormone panel and…
- 05:11 throughout the day you want to keep your blood glucose steady without…
- 05:27 I started using levels a little over a year ago and it…
- 00:55:13 They're both thermodynamically favorable, they allow glucose sparing, they allow glucose to…
- 14:34 you are fasting, at least for four hours, the only way you…
- 01:42:55 glucose is toxic when you have too much of it... the chronic…
- 01:48:07 it was like night and day difference in My My My fasting…
- 01:49:00 the average blood glucose the lower it is the better you are…
- 01:50:54 an average blood glucose of 100 on a CGM would be better…
- 01:51:55 that hit class that you were doing probably in the short term…
- 01:10:10 my current interpretation is that it probably is operating by blocking very…
- 01:37:19 something about aging in the male mice depends a lot on staying…
- 01:38:14 why high glucose is bad for cancer is a relatively straightforward question…
- 02:12:52 our muscles are a sink for glucose they are the single most…
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Rapamycin 98
- 73:48 the ITP was the first study that really put rapamycin on the…
- 01:38 the two drugs i get asked about more than all other drugs…
- 02:03 their potential for reducing the risk of saros cov2 infection or other…
- 06:36 Novartis had a rapamycin analog and there was a lot of data…
- 12:36 older mice given rapamycin that vaccination response was improved
- 00:21:01 when they added rapamycin to metformin to rapamycin you could say if…
- 01:17:56 Joan, I started taking metformin in 2010, that's when I sort of…
- 01:18:37 The reason I chose metformin, it's not because it was the best…
- 96:15 never getting one again until i started rapamycin you know 12 14…
- 96:24 one other little thing i've noticed which is really odd is when…
- 01:55 certainly with respect to the podcasts around rapamycin and metformin
- 00:44:58 rapamycin is one of the candidate drugs who brought that to the…
- 00:45:30 rapamycin is that drug and it's actually safe enough that you can…
- 00:45:43 randy strong noticed first of all that when you gave it to…
- 00:46:22 the first drug that gave a very strong signal in both males…
- 00:53:12 when you give the same dose of rapamycin in chow, the blood…
- 00:57:52 so that means of the drugs that we've tested for late start…
- 00:59:12 what we've learned about rapamycin since that time is it inhibits two…
- 01:02:23 the basic idea that knocking down TOR complex one might be a…
- 01:05:18 randy strong and marty javers and their colleagues at the university of…
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alcohol 82
- 01:24:50 if you're a chronic Drinker of alcohol you tend you you will…
- 01:25:37 moderate drinking is up is impacting your brain function but not only…
- 01:27:01 chronic drinking is uh is uh of course people will have a…
- 00:60:46 did you tell them not to drink because alcohol has such a…
- 01:01:13 if I had a magic wand I would ask that people either…
- 01:01:24 it certainly disrupts patterns of nighttime sleep in particular my understanding that…
- 01:31:55 too much alcohol
- 37:04 Looking at epidemiology, you see certain lifestyle factors for example, drinking. If…
- 03:48:04 I'm in the camp that believes there is absolutely no benefit to…
- 13:18 so now I'm reaching for three or four cups of coffee the…
- 14:00 alcohol if we're thinking about classes of drugs they're in a class…
- 15:22 the third part of alcohol in terms of an equation is that…
- 16:52 metabolic Health improve overnight like you could take somebody who's an alcoholic…
- 00:35:47 When they... process fish oil, they process it in ethanol and alcohol,…
- 77:57 I went sober for six months really loved it, most to do…
- 78:51 with the rise of sleep trackers I think you really have some…
- 00:07 it impacts our Behavior our sleep our mood and many other parts…
- 00:13 higher risk drinking would be if you're having more than 10 ounces…
- 00:20 we reach for the alcohol at night but we don't really understand…
- 03:03 do you even know what's happening in your body and your brain…
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Creatine 81
- 01:53:44 the number one is creatine, creatine for women doesn't matter what age…
- 00:11 when it comes to set two three and four that's where creatine…
- 00:17 they measured it for 21 hours of sleep deprivation and it really…
- 01:32 anybody on the planet is now considering creatine either in their diet…
- 01:55 it basically increases the ability to produce ATP or maintain it during…
- 05:40 compare creatine and weight training to creatine Placebo and weight training there…
- 06:02 does it affect the recovery time in between sets excellent question it…
- 08:38 the improvements in the muscle strength presumably are coming because you're increasing…
- 00:12:09 creatine sort of attenuate that rise could allow the individual to recover…
- 00:12:57 creatine's anti-inflammatory properties would come into play
- 00:13:28 creatine doesn't directly increase protein synthesis which might be a surprise for…
- 00:14:23 creatine seems to help increase muscle size in other ways satellite cells…
- 00:14:39 does creatine have a general anti-inflammatory effect in in both males and…
- 16:42 carnivore diet but an elegant study out of Brazil about four years…
- 17:27 Creatine is most found in animal Foods Meats poultry fish yes um…
- 18:37 the thought is as we get older we have R reduced fossil…
- 19:53 Roger Harris came up with a seminal uh um protocol where you…
- 22:27 I mentioned five grams a day and well maybe before we get…
- 25:24 Creatine reduces something called the osteoclast activity or bone resorption so for…
- 00:27:50 just supplementing with creatine by itself even if you're doing 8 G…
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Vitamin D 79
- 23:28 Vitamin D deficiency is really some sort of accelerated aging? Is that's…
- 24:27 And it seems like vitamin D somehow is able to elicit the…
- 24:40 It requires Nrf2 in the worm to see the beneficial effects on…
- 25:04 You could see how an effect on a global process like protein…
- 29:41 People that had blood levels between 40 and 60 nanograms per milliliter…
- 00:30:22 I think that it's absolutely probably regulating the aging process and this…
- 00:30:44 And I'm not an MD and I am not prescribing vitamin D…
- 00:31:14 It's probably almost completely harmless to be taking an additional 1,000 units…
- 00:31:22 You know, they should get their D levels measured before and after…
- 03:07:31 I wonder if avoiding vitamin D deficiency also becomes one of those…
- 03:06:20 what do we know about the relationship between call it naturally acquired…
- 03:07:13 the actual 125 hydroxy vitamin D which is the active steroid hormone…
- 03:08:26 supplementing above that would be a bad idea it yeah like and…
- 03:11:49 I'm always kind of like hovering around 50 60 but I'm like…
- 03:12:26 estrogen can actually compensate for um vitamin D deficiency in some cases…
- 29:04 I take vitamin D... I take 5000 IU of vitamin D.
- 39:20 I don't think I was taking a baby aspirin a year ago…
- 00:33 Most recently, Bruce and I have co-authored two papers together, one that…
- 00:39 And the second paper which was just recently accepted for publication is…
- 00:39:52 Plus, genetics is really important, too. So if you have a polymorphism,…
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Omega-3 61
- 00:24:28 omega-3 being one of you know at the Forefront of um one…
- 43:08 I remember reading um a couple of studies years ago where uh…
- 43:14 Omega-3 deficiency also breaks down blood-brain barrier.
- 44:59 I'll send you my paper I wrote a a sort of interactive…
- 45:47 Omega-3 the fact that you give omega-3 tune to aged animals and…
- 00:55:52 people so air particulate matter so when you have like air pollution…
- 00:56:43 this uh kind of vicious cycle where omega-3 may play a major…
- 00:59:52 it makes me wonder about filtering out the air I mean if…
- 00:02:52 we knew nothing about Dr. Dyerberg and Bang and Eskimos at this…
- 06:23 the work of the danish investigators dyerburg and bang and greenland eskimos…
- 07:01 supplement manufacturers were starting to make omega-3 and make claims that they…
- 09:00 we studied platelets we got a hematologist on board scott goodnight and…
- 11:26 we did one big study where we were doing open-heart surgery on…
- 12:15 that got the omega-3 than the placebo less need for transfusion which…
- 15:39 there have been some studies on omega-3 playing a preventative role in…
- 19:44 vegetarian or vegan would be an algal oil so the original source…
- 22:45 the omega-3 index being an important risk factor for cardiovascular disease
- 25:17 just eat more fish or take supplements and you can raise your…
- 25:52 we called it the omega-3 index we didn't really know what to…
- 28:41 the plasma has certainly has omega-3 and you can express the plasma…
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Testosterone 61
- 00:17:36 in your 20s that's when you want to do some base casing…
- 69:29 I'm now clear on the fact that a woman in her late…
- 01:19:17 PCOS which is hyper androgenization of the ovary in there we're talking…
- 01:22:10 the thread we haven't talked about with PCOS is the the role…
- 02:09:20 when a woman asks for a hormone panel and she's not trying…
- 01:28:45 Baseline testosterone is and we know that there's a greater inflammatory response…
- 02:04:48 cooling the testicles leads to increases in testosterone which is on the…
- 01:54 We also discuss testosterone therapies not just for men but for women,…
- 00:33:25 he had been using and I would say abusing both testosterone and…
- 00:46:51 peptides can be hormones there are things like oxytocin is sometimes called…
- 02:38:15 obviously what happens in menopause is three hormones that are really important…
- 02:39:21 testosterone could be a 100 times higher than your testosterone so it's…
- 02:41:03 we know testosterone plays an important role in libido and we know…
- 03:13:40 testosterone replacement in women uh postmenopause and this is something that is…
- 03:17:37 would we be comfortable using testosterone in isolation without opposition um I…
- 03:18:18 everything is bespoke and I and I think that that's just really…
- 03:39 you know your total testosterone might be below the 30th percentile or…
- 04:40 if a guy is at 8 and we have the the case…
- 06:16 we recommend an injection we also recommend instead of doing it every…
- 07:04 testosterone replacement therapy does not increase the risk of prostate cancer
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Insulin 53
- 00:08:06 people's diabetes was like going away, they were having normal blood sugar…
- 17:47 we're looking at people who had insulin resistance long enough that their…
- 01:16:07 this insulin that you're going to inject to you okay and i'm…
- 02:09:36 obesity is not an energy balance problem it's a hormonal regulatory disorder
- 02:29:56 first thing that have first observable effect from the bmh lesion is…
- 01:51:49 i would expect uh an enormous increase in insulin to produce that…
- 01:56:58 both animals are obese both animals are hyperinsulinemic from weaning onward
- 02:41:46 the energy balance hypothesis thinking was i like to say not even…
- 00:31:00 he's tracked his glucose and Insulin going back 20 years so he…
- 01:22:10 the thread we haven't talked about with PCOS is the the role…
- 01:24:46 I wish I knew what my insulin was when I was a…
- 01:35:56 I went to the lab and I ran a hormone panel and…
- 22:06 that is the definition of insulin resistance the cell is becoming resistant…
- 25:32 enter metformin first line drug so most of the drugs so every…
- 00:50 Dr. Conover's expertise is in the use of exogenous peptides for activating…
- 01:41:19 muscle is the sink for glucose disposal and there are two ways…
- 28:40 So as you get older, our muscles and our brain become less…
- 00:33:31 store it as glycogen which is sugar or it can store it…
- 00:34:00 in the FED State insulin goes up you're storing calories or body…
- 00:34:48 the only way that you can actually use the body fat is…
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NAD 51
- 02:00 As well as things like NAD as well as specific supplements Dr.…
- 01:53:16 the dosage of 750 milligrams is actually what we came up with…
- 01:56:18 I had a patient he was diagnosed with a chronic Epstein bar…
- 01:59:31 how often do you encourage your already healthy patients to do NAD…
- 01:23:55 One agent one thing it's NAD has been the most impactful from…
- 01:24:11 500 milligrams to 750 or 1000 milligrams that one brings in IV.
- 33:09 NAD has emerged as one of these critical intermediary metabolites. Think of…
- 33:34 And NAD is a hydride acceptor. While we oxidize foods, it can…
- 00:36:20 So one of the main enzymes that repairs damage as we age,…
- 00:36:42 I completely agree, and so there are two major theories right now…
- 00:37:14 we can get NAD from the food, but also we salvage the…
- 00:39:26 Nicotinamide riboside? Yes, for example, the paper we’ve published was focused on…
- 01:50:01 nad and its chemical derivatives would surely be on that list
- 01:50:14 there's a great deal of pretty strong data suggesting that aspects of…
- 31:12 And even though you're exercising as you get older, you're not getting…
- 31:39 But we found a way to restore the youth of the muscle…
- 12:08 NAD stands for nicotinamide, which is vitamin B3, and adenine dinucleotide.
- 12:48 It activates the sirtuins and the sirtuins are these defensive enzymes that,…
- 00:18:59 NR doesn't seem to be as effective as NMN.
- 00:30:29 NAD IVs, do they work? My answer has to be we don't…
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- 00:07:53 we opened the clinic as a carbohydrate restricted clinic
- 00:10:00 dr hallberg told them to eat a lot of fat and not…
- 00:35:19 they did a run in with a very low carbohydrate diet for…
- 00:41:32 high carbohydrate low carbohydrate low fat here on the left to a…
- 01:09:45 we know very low levels of carbohydrate restriction can reverse the disease…
- 01:11:39 the majority of people can reverse their disease, get normal glycemia, get…
- 01:12:42 the fact that people were on the incredibly high dose of insulin,…
- 01:56:49 apparently people stopped eating fat and eating more carbohydrates and that got…
- 02:06:55 it's the carbohydrates that do it and we can't eat carbs but…
- 02:08:44 the first third of good calories bad calories is the deconstruction of…
- 01:31:26 by the mid 1960s you have very well established science of what…
- 01:58:34 we on one that had a carbohydrate insulin model like we did
- 01:58:39 the researchers who believe the conventional wisdom interpreted their results as supporting…
- 23:18 if you're going to do any kind of cardiovascular type work up…
- 09:19 One camp says IGF-1 is driven exclusively by amino acids. The other…
- 01:35 The second one is nutrition, and there’s a lot of research going…
- 05:25 You can walk into any store and find low-fat diet and low-fat…
- 07:09 the carbohydrate intake and the insulin signaling pathway, these things, carbohydrates regulate…
- 08:30 So, one is decreasing carbohydrate intake. So, that would lead to a…
- 00:39:49 it's pretty clearly observed from a dietary pattern perspective that carbohydrate restriction…
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NMN 48
- 01:54:28 I take sublingual NMN each day. It makes my hair grow ridiculously…
- 01:55:38 NR can reduce inflammation, is that right? Yeah, okay, less data that…
- 00:57 Should I take NR? Should I take NMN? What should I do…
- 00:18:59 NR doesn't seem to be as effective as NMN.
- 00:22:52 When we supplement with NMN, when NMN is given to organisms in…
- 00:24:18 Shin Imai showed that it actually was pretty good at slowing down…
- 00:24:36 We've reported that out in the scientific community. They seem to be…
- 00:24:49 The doses are out 400mgs per kg.
- 00:26:46 I know a fair bit about the effect of NAD boosters in…
- 00:27:32 Yoshino et al. in 2021 showed increase insulin stimulated glucose disposal.
- 00:31:07 Alcohol dehydrogenase needs NAD. And so what's probably happening is when you…
- 65:09 I take one gram of NMN every morning along with my resveratrol.…
- 66:42 I went on NMN and things were somewhat rectified.
- 67:32 when the mice took it their endurance got better
- 69:06 he's on NMN and resveratrol, mainly
- 70:12 what i do is listed on page 304 of my book so…
- 02:23:00 I do take sublingual nmn but it's very important but I don't…
- 02:23:35 nmn is a precursor to NAD; NR is the precursor to nmn…
- 00:12:05 There are really kind of four NAD precursors that people think about…
- 00:12:43 NMN and NR cost about 100 times more than nicotinamide and niacin…
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Resveratrol 42
- 78:49 resveratrol did not go through our usual screening process. This was a…
- 80:15 resveratrol given to mice on a normal diet does not extend their…
- 01:36:31 there's actually a study came out very recently r veratrol doing it…
- 02:02:18 the evidence that it works is very bad it it almost certainly…
- 08:10 And so we're going to talk about NAD boosters. We're going to…
- 37:11 The one that was the best at the time, which activated 13…
- 37:51 You can't drink enough red wine to get the kind of doses…
- 38:29 The minimum that I've seen is 250 milligrams a day. And some…
- 39:03 Resveratrol is the equivalent of brick dust, it's really insoluble.
- 41:06 Resveratrol has been shown to reduce fasting glucose and significantly increase insulin…
- 00:43:00 red wine has more than resveratrol and it has some of these…
- 68:04 Let's take this morning through night just really quickly. Resveratrol, one gram.…
- 00:58:47 For example, resveratrol, spermidine are considered fasting-mimicking drugs.
- 49:14 taking resveratrol which is a plant molecule that comes mostly from red…
- 50:06 resveratrol and some other plant polyphenols are highly insoluble once you pull…
- 69:06 he's on NMN and resveratrol, mainly
- 70:12 what i do is listed on page 304 of my book so…
- 01:24:04 So CERT1 is the enzyme that we work on in my lab…
- 00:09 the initial claims that resveratrol could increase lifespan delay aging um have…
- 00:51 there was a meta analysis done I think it was published last…
