Bill Harris

  • Professor of Medicine at Stanford University
  • Senior Research Scientist at the Longevity Institute

Credentials

  • MD
  • PhD in Gerontology

Education

  • MD – Harvard University (1982)
  • PhD in Gerontology – University of California, Berkeley (1988)

Affiliations

  • Stanford University
  • Longevity Institute

Research Focus

  • Cellular and Molecular Mechanisms of Aging
  • Nutrition and Longevity
  • Genetic Determinants of Longevity

Notable Publications

  • The Cellular and Molecular Basis of Age-Related Disease (1991)
  • Nutrition and the Science of Longevity (1999)
  • Genetic Blueprints: The Impact of Genes on Longevity (2006)

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Awards & Honors

  • Geron Society's Robert W. Kleemeier Award (2001)
  • National Institute on Aging's Nathan Shock Award (2008)

Key Contributions

  • Pioneered research on the role of genetics in human longevity and its implications for age-related diseases.
  • Revealed the impact of diet and nutrition on overall lifespan and healthy aging.

Contact

contact@billharrislongevity.com

Other Resources

Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 2:52 0
“we knew nothing about Dr. Dyerberg and Bang and Eskimos at this point, we just hadn't shown up on our radar. They had published their stuff, I just didn't know about it.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 3:07 0
“Fish oil is from an animal but it's liquid, so it's got this kind of cuts across and so he said well let's see what high fish oil diet does to cholesterol levels.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 3:19 0
“we had three groups you know saturated fat, control, polyunsaturated fat and fish oil and that's when we were doing our very high dose you know drink a half a cup of salmon oil every day for our volunteers.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 3:44 0
“that's when we discovered that it lowered triglycerides because we weren't looking for that we were looking for cholesterol effects.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 6:23 0
“the work of the danish investigators dyerburg and bang and greenland eskimos linking omega-3 with reduced atherosclerosis that was becoming well-known then”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 7:01 0
“supplement manufacturers were starting to make omega-3 and make claims that they lowered lowered cholesterol levels because we did see a lowering cholesterol in the both the vegetable oil group and the salmon oil group”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 9:00 0
“we studied platelets we got a hematologist on board scott goodnight and we did all kinds of platelet studies. Platelet aggregation was reduced by the omega-3 uh bleeding time was reduced”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 11:26 0
“we did one big study where we were doing open-heart surgery on people trying to pre-load them with omega-3 before open-heart surgery this was a dr moserfarian's study opera study and we're trying to prevent post-op afib by giving him a big load of omega-3 ahead of time”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 12:15 0
“that got the omega-3 than the placebo less need for transfusion which was kind of cool I mean that that is not that we would advocate it for reducing risk for bleeding but it's not increasing risk for bleeding interesting”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 12:57 0
“the FDA in their package insert for Lovaza and Vascepa they say does not cause clinically significant bleeding.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 13:19 0
“Lovaza is the EPA plus DHA ethyl ester, Vascepa is an EPA-only ethylester.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 15:39 0
“there have been some studies on omega-3 playing a preventative role in pulmonary embolisms.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 19:44 0
“vegetarian or vegan would be an algal oil so the original source of epa and dha in a fish is not that they make omega-3 they don't really make omega-3 any better than we do or make epa and dha they eat pre-formed epa and dha and it comes from their food sources which at the bottom of the food chain is these micro single celled micro”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 20:30 0
“different companies have identified which strains specific strains of algae microalgae will make dha or epa or both and they've commercialized or they've industrialized it and they harvest the oil it's an expensive process at this point”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 20:50 0
“if we can get over the gmo issue there are two or three groups that have found ways to put genes into plant or land plant animal land plants that can be grown you know as long as you've got ground you can grow them um camelina is one even soybean oil which starts with ala you can get up to a fair amount of dha epa and dha with genetic engineering of these plants”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 22:45 0
“the omega-3 index being an important risk factor for cardiovascular disease”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 25:17 0
“just eat more fish or take supplements and you can raise your omega-3 levels and reduce risk”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 25:52 0
“we called it the omega-3 index we didn't really know what to call it didn't want to call it red blood cell epa plus dha is too much and we picked red blood cells because that had been used in past studies and it makes sense because it's a long-term marker of omega-3 status because the omega-3s are in the membrane of the red cell and in most other tissues in the body all other tissues”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 28:41 0
“the plasma has certainly has omega-3 and you can express the plasma omega-3 content as a percent of total plasma fatty acids it's just that the number you get like in normal might be two percent for plasma epa dha whereas for red blood cell epa dha which is just the red cell membrane it might be five or six percent would be normal”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 31:38 0
“the omega-3 index is better indicator of brain than plasma”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 32:42 0
“there is quite a bit of background variability in the omega-3 index”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 34:54 0
“some people actually may require a much larger dose of omega-3”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 36:11 0
“in an ideal world for every randomized controlled trial you do, you obviously need to measure something like the omega-3 index at baseline and after treatment”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 38:12 0
“that's why it's important to titrate the omega-3 any given patient you know you just don't ask them how much fish they eat and call it good”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 41:00 0
“the most successful omega-3 trial in years was reduce it with four grams of epa and they they reported that the most the only risk factor they could measure or thing in the blood that they measured that would predict outcomes it was better than cholesterol better than triglycerides was the omega-3 level was the omega-3 level achieved that was the strongest predictor of benefit in the reduced trial”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 43:38 0
“you might want to go down to your local drugstore and pick off a bottle of fish oil and just take it and don't tell anybody or at the very least you can do your fish intake or start eating more fish”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 44:00 0
“omega-3 is probably the easiest one of the easiest nutrients to study like a drug of all the nutrients because our background intake is so little and that there's so little metabolism in vivo metabolism of omega-3”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 45:27 0
“average americans roughly 5 omega-3 index which is epa and dha in red cells as a percent of the total fatty acids in the red cells so five percent of the fatty acids in the red cell membrane epa and dha japan it's on average nine percent”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 46:10 0
“we like to say be over eight percent that's the goal that's been our target so you can get up to about 15 or 16 we have seen two or three people out of hundreds of thousands that are over 20”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 49:46 0
“correlated the omega-3 index to cause mortality is able to even predict uh mortality very very interesting study um i shared it on social media but i would love to talk about it yeah yeah sure that was a it's gonna be probably one of my capstone studies i think in in hindsight um it was a collaboration among 17 different cohorts like like the framingham studies of cohort women's health initiatives mesa epic these are all and from all around the world these are groups that have been recruited at one point in time blood samples taken fatty acid levels measured in that blood and then the investigators just follow this group of people over time to see what happens what kind of diseases they get you know who gets who dies who doesn't and so we had 17 of those pooled together and around 40 45 000 people all together where we had omega-3 levels at the beginning and then roughly um the total follow-up time when you're when you're looking at risk for death all cause mortality you obviously look in a given window of time because if you wait long enough it's one hundred percent everybody…”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 56:49 0
“if you have a low omega-3 and you're non-smoker, it's not so bad, your risk of death maybe is 30 over the if you're a smoker and you have a high omega-3 that's the other flip side but you're a smoker your risk is kind of like having a low omega-3 being a non-smoker.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 57:36 0
“smoking actually lowers the omega-3 index, smokers have lower omega-3 index than non-smokers.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 58:14 0
“having a high omega-3 level is protective and in the same sense that having low cholesterol is protective in the same sense that having low blood pressure is protective.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:01:22 0
“giving omega-3 does lower inflammatory levels.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:03:54 0
“it's actually a bewildering array of molecules that have been discovered made from epa and dha that operate on different cell types and different receptors through different mechanisms but at the end of the day they suppress an inflammatory response and keep it from getting out of control.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:04:31 0
“what we saw in framingham was all these mediators are are inversely related to the omega-3 level and these people aren't chronically inflamed.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:06:54 0
“i think much more likely to be an anti-inflammatory mechanism and anti-platelet so thinner blood less likely to clot.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:09:21 0
“we've seen that we've got a data set of 40 some thousand people we see the very strong correlation between high omega-3 and lower healthier rdw and we're getting ready to submit that now”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:09:35 0
“the ways that omega-3s may be protective we may have never thought of yet still which makes it hard to explain to people how they work”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:12:16 0
“raising your omega-3 index is going to have implications all over the body that may not be even measurable in a blood test”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:12:44 0
“we published a study looking at the omega-3 index and COVID-19 associated mortality”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:15:24 0
“the higher the average fish intake the lower the risk of death and covet”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:16:10 0
“they found that DHA, again in silico experiments, if it's present will hold that thing in a closed position.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:17:20 0
“it also showed that linoleic acid did the same thing.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:19:15 0
“the omega-3 to omega-6 ratio is so important everyone's so concerned about eating too much omega-6”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:21:22 0
“we published two papers with this consortium of the 17 or 20 cohorts we've had several other papers all looking at fatty acids and some outcome and one of them looked at linoleic acid levels in the blood and cardiovascular outcomes and found that the higher the linoleic acid the lower the risk for cardiovascular disease and another paper looked at linoleic acid levels and risk for developing diabetes higher omega-6 linoleic lower risk for developing diabetes”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:22:54 0
“2013 paper that was published by yeah um yes and he looked at blood omega-3 levels i don't know if it was platinum plasma phospholipids yeah omega-3 and the incidence of prostate cancer in a trial of people was called the select trial where people were given high dose alpha tocopherol and or selenium selenium right um and he found a correlation between the plasma phospholipid phospholipid omega-3 and right prostate cancer”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:27:17 0
“two to three grams a day from supplements um i don't really have a favorite supplement i kind of maybe like your friend in norway i if people send me supplements oh yeah try this um and then salmon probably once a week for sure try to do more but at least once a week uh so my index is around 10.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:28:47 0
“epinova which is a epa plus dha same ratio is in lavazza except they're free fatty acids not ethyl esters so they're unasterified epa and dha which which they had previously shown are more readily absorbed.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:28:53 0
“the trouble with those is they're also pretty irritants their gi irritants free fatty acids are so they had to encapsulate they had to um entirely coat the pills.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:34 0
“taking 840 milligrams there's a one capsule levasa”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:40 0
“it's four grams a days which is really five times higher than anybody's ever used before for omega-3 dosing”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:57 0
“if they know that they can increase their omega-3 index by you know supplementing with omega-3 and or increasing their you know fatty fish like salmon or sardines that have high omega-3 in it to prevent and stave off dementia”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:39 0
“looking at 70 trials in pregnant women given omega-3 that the giving omega-3 reduces risk for premature birth especially early premature birth before 34 weeks”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:40:01 0
“in that trial unfortunately there was apparently compliance with dha supplementation was not very good so the change in omega-3 index was not much in that big trial so they didn't see a benefit it could be because women weren't taking it”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:40:35 0
“we do have a test we developed in omega quant called the rbc mother's dha test rbc dha test i can't remember the name of it um i'm gonna get in trouble uh but anyway it's it's a test for pregnant women to measure their red cell dha levels and we think being over five percent is where you want to be”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:42:05 0
“there's plenty of evidence that having a higher omega-3 level in mom i mean it's mixed evidence as is everything if you look several years down the road kids do are doing better in some studies yeah they're not doing worse they're either doing no different or better”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 1:47:04 0
“you want to be careful to give omega-3 if you're giving that high a dose to people you might want to be a little more attentive to afib but there's no increased risk for stroke there's actually decreased risk for stroke which would be the clinical outcome of an afib right event”

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