Anastrozole
Anastrozole is a medication used primarily in the treatment of breast cancer in post-menopausal women. It is a non-steroidal aromatase-inhibiting drug that lowers estrogen level, which can promote the growth of breast cancer cells.
- Category
- Pharmaceutical
- Molecular Formula
- C17H19N5
- Mechanism of Action
- Anastrozole works by inhibiting the enzyme aromatase, which is responsible for the conversion of androgens to estrogens in the body. This leads to decreased estrogen levels, thereby slowing the growth of certain types of breast cancers that need estrogen to grow.
- Evidence Grade
- A
Other Names
Primary Benefits
- Reduces the risk of breast cancer recurrence
- Slows the growth of breast cancer cells
Recommended Dosage
| Adults |
1 mg orally once per day |
| Children |
Not recommended |
| Elderly |
Same as adult dosage |
Side Effects
- Hot flashes
- Weakness
- Joint pain
- Carpal tunnel syndrome
- Nausea
- Vomiting
Precautions
- Not for use during pregnancy or breastfeeding
- Regular bone density tests may be needed
- Monitor cholesterol levels as it may increase
Interactions
- Estrogen-containing therapies
- Tamoxifen
- Certain cholesterol medications
Key References
- https://www.ncbi.nlm.nih.gov/pubmed/11807163
- https://www.ncbi.nlm.nih.gov/pubmed/10571676
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