Apigenin

No summary available for this substance.

Apigenin

Apigenin is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used in dyeing wool. Apigenin is found in many fruits and vegetables, but can also be consumed in supplement form.

Category
Bioactive Compound
Molecular Formula
C15H10O5
Mechanism of Action
Apigenin has been shown to inhibit the expression of several inflammation-related cytokines and chemokines. It also displays a variety of actions on cellular function, including inhibiting cell growth, inducing apoptosis, and reducing inflammation.
Evidence Grade
C

Other Names

  • Chamomile
  • Celery
  • Parsley

Primary Benefits

  • Anti-inflammatory
  • Antioxidant
  • Potential anti-cancer properties

Recommended Dosage

Typical Dosage 50-100mg per day
Maximum Dosage Not established

Side Effects

  • Allergic reactions
  • Mild stomach upset

Precautions

  • Not recommended for pregnant or breastfeeding women
  • Check with your doctor if you have a medical condition

Interactions

  • Interacts with blood thinners
  • May interact with sedatives

Key References

  • Shukla, S., & Gupta, S. (2010). Apigenin: a promising molecule for cancer prevention. Pharmaceutical research, 27(6), 962-978.
  • Patel, D., Shukla, S., & Gupta, S. (2007). Apigenin and cancer chemoprevention: progress, potential and promise (review). International journal of oncology, 30(1), 233-245.
Boost Your Energy & Immune System with Cortisol & Adrenaline | Huberman Lab Essentials
Optimize Energy and Immunity Naturally with Hormone Regulation Practices 25:35 0
“the other compound that I think deserves attention is apigenin, which is what's found in chamomile. I take it before bedtime, 50 milligrams. The major source of action is to calm the nervous system and it does that primarily by adjusting things like GABA and chloride channels but also has a mild effect in reducing cortisol.”

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Dr. Peter Attia: Supplements for Longevity & Their Efficacy
Supplements, Lifestyle, and Strategies for Longevity and Optimal Health 1:41:58 0
“before sleep I take magnesium 3 and8 I'm really bullish on magnesium as well appenine 50 milligrams which is essentially chamomile extract and theanine and occasionally I'll take 900 milligrams in netl also um or instead I kind of mix those up and around”

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