Aromatase Inhibitors
Aromatase inhibitors are a class of drugs that systematically block the enzyme aromatase, which is responsible for the final step in the body's synthesis of estrogen. By blocking this enzyme, these drugs effectively reduce estrogen levels in the body, which can be beneficial in conditions that are sensitive to this hormone, such as certain forms of breast cancer.
- Category
- Drug/Supplement
- Molecular Formula
- Varies by specific inhibitor
- Mechanism of Action
- Inhibits the enzyme aromatase, thereby reducing the production of estrogen in the body.
- Evidence Grade
- A
Other Names
Primary Benefits
- Used in the treatment of hormone receptor-positive breast cancer
- May help manage symptoms of endometriosis
Recommended Dosage
| Adults |
Varies depending on the specific aromatase inhibitor and condition being treated, typically administered daily. |
| Children |
Not typically recommended for children |
Side Effects
- Hot flashes
- Joint pain
- Weakness
- Mood changes
- Nausea
- Bone loss
Precautions
- Not recommended for pregnant or breastfeeding women
- Regular monitoring of bone density may be required
Interactions
- Certain other medications, such as tamoxifen
- Certain health conditions, such as osteoporosis
Key References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074482/
- https://www.cancer.gov/about-cancer/treatment/types/hormone-therapy/aromatase-inhibitors
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