Arsenics
Arsenic is a naturally occurring chemical element. It is found in several forms (species), but inorganic arsenic compounds are the most toxic to human health. Some forms of arsenic have been used in medicine and dietary supplements due to their potential health benefits, predominantly in traditional Chinese medicine. However, the safety of arsenic consumption is highly controversial due to its well-known toxicity and carcinogenic properties.
- Category
- Inorganic compound
- Molecular Formula
- As2O3
- Mechanism of Action
- Arsenic trioxide induces apoptosis and has antineoplastic activity. It also disrupts mitochondrial transmembrane potential and induces reactive oxygen species production leading to cellular apoptosis.
- Evidence Grade
- A (Strong scientific evidence for its use in acute promyelocytic leukemia)
Other Names
- Arsenic trioxide
- Arsenous acid
- Arsenic(III) oxide
Primary Benefits
- Used to treat acute promyelocytic leukemia
- Used in traditional medicine for various conditions
Recommended Dosage
| Adults |
For acute promyelocytic leukemia, 0.15 mg/kg intravenously once daily until bone marrow remission |
| Children |
Not recommended |
Side Effects
- Nausea
- Vomiting
- Abdominal pain
- Fatigue
- Shortness of breath
- Prolonged QT interval
Precautions
- Avoid in pregnant or breastfeeding women
- Avoid in patients with heart disease
Interactions
- Increased toxicity with other chemotherapy or immunosuppressive agents
- May interact with certain heart medications
Key References
- https://www.cancer.gov/about-cancer/treatment/drugs/arsenictrioxide
- https://pubchem.ncbi.nlm.nih.gov/compound/Arsenic-trioxide
No comments yet.