Avastin

Avastin

Avastin, also known as Bevacizumab, is a type of medication called a monoclonal antibody. It is used to treat various types of cancers by interfering with the growth and spread of cancer cells in the body. It works by blocking a certain protein (an antibody) that may help cancer cells to grow.

Category

Antineoplastic agent

Molecular Formula

C6638H10160N1720O2108S44

Mechanism of Action

Avastin works by blocking the action of a protein called vascular endothelial growth factor (VEGF). By blocking VEGF, Avastin prevents the growth of new blood vessels, cutting off the supply of oxygen and nutrients the tumor needs to grow.

Evidence Grade

A

Other Names

• Bevacizumab
• rhuMab-VEGF

Primary Benefits

• Slows the growth of new blood vessels
• Inhibits the growth and spread of cancer cells
• Can be used in combination with other cancer treatments

Recommended Dosage

Side Effects

• High blood pressure
• Fatigue
• Bleeding
• Poor wound healing
• Gastrointestinal perforations

Precautions

• Not recommended for use in pregnant or breastfeeding women
• Patients with hypertension should have their blood pressure adequately controlled
• Patients should have adequate wound healing before starting therapy

Interactions

• May interact with sunitinib
• May interact with sorafenib
• May interact with other chemotherapy agents

Key References

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535097/
• https://www.cancer.gov/about-cancer/treatment/drugs/bevacizumab