“the final drug so we can just wrap this up because I'm sure the listeners are tired of hearing about this stuff uh is a is a drug called bidic acid that is a prodrug so it's a very elegant drug uh it's taken as a pill uh but it's ineffective until it's metabolized by the liver and in the liver it then inhibits um cholesterol synthesis what makes this drug special is unlike statins this drug only works in the liver so statins work throughout the body they do most of their work in the liver but technically every cell is impacted by a Statin only hepatocytes are impacted by bondic acid and it lowers apob same way lowers cholesterol synthesis liver says I need more cholesterol puts more LDL receptors up pulls more LDL in LDL and cholesterol go down but no side effects no type to diabetes risk nothing nothing it's just it's only acting in the liver.”
Main Takeaways:
- Bempedoic acid (bidic acid) is a prodrug that only becomes active in the liver, where it inhibits cholesterol synthesis.
- It is unique in that it only affects hepatocytes, unlike statins which impact every cell.
- This drug lowers cholesterol effectively with no reported side effects or diabetes risk.
Notes: Discussion on the unique properties of bempedoic acid compared to other drugs.
Tone: Enthusiastic
Relevance: 5/5
“it increases LDL receptor expression on its surface and pulls more LDL out of circulation so that's how both statins and bempedoic acid work they work indirectly”
Main Takeaways:
- Statins and bempedoic acid increase LDL receptor expression.
- This action helps to remove LDL cholesterol from the bloodstream.
- Both substances work indirectly to manage cholesterol levels.
Notes: Discussion on cholesterol management
Tone: Informative
Relevance: 5/5
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