beta ameloid and Tow protein

beta ameloid and Tau protein

Beta-amyloid is a sticky compound that accumulates in the brain, forming plaques. It's thought to be involved in Alzheimer's disease. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are often defective in neurodegenerative diseases.

Category

Protein

Molecular Formula

Not applicable

Mechanism of Action

Beta-amyloid forms plaques that disrupt cell function. Tau proteins stabilize microtubules when tau is hyperphosphorylated, it can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathology of Alzheimer's disease.

Evidence Grade

A

Other Names

• Aβ
• beta-A4
• Tau

Primary Benefits

• Understanding the roles of these proteins can lead to potential treatments for neurodegenerative diseases

Recommended Dosage

Precautions

• Not applicable

Key References

• Hardy, J.; Selkoe, D. J. (2002). 'The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics'. Science. 297 (5580): 353–356.
• Goedert, M.; Spillantini, M. G. (2006). 'A century of Alzheimer's disease'. Science. 314 (5800): 777–781.