“the final drug so we can just wrap this up because I'm sure the listeners are tired of hearing about this stuff uh is a is a drug called bidic acid that is a prodrug so it's a very elegant drug uh it's taken as a pill uh but it's ineffective until it's metabolized by the liver and in the liver it then inhibits um cholesterol synthesis what makes this drug special is unlike statins this drug only works in the liver so statins work throughout the body they do most of their work in the liver but technically every cell is impacted by a Statin only hepatocytes are impacted by bondic acid and it lowers apob same way lowers cholesterol synthesis liver says I need more cholesterol puts more LDL receptors up pulls more LDL in LDL and cholesterol go down but no side effects no type to diabetes risk nothing nothing it's just it's only acting in the liver.”
Main Takeaways:
- Bempedoic acid (bidic acid) is a prodrug that only becomes active in the liver, where it inhibits cholesterol synthesis.
- It is unique in that it only affects hepatocytes, unlike statins which impact every cell.
- This drug lowers cholesterol effectively with no reported side effects or diabetes risk.
Notes: Discussion on the unique properties of bempedoic acid compared to other drugs.
Tone: Enthusiastic
Relevance: 5/5
“you can take Metformin or an sgt2 inhibitor or a glp1 Agonist and you will directly impact those things you could take uh a pcsk9 inhibitor or a Statin or bidic acid you will directly impact those disease processes you will delay the onset of those diseases and you will reduce the mortality associated with them”
Main Takeaways:
- Certain medications can directly impact and delay the onset of diseases.
- Using specific drugs can reduce mortality associated with chronic diseases.
Notes: Speaker discussing pharmacological interventions for longevity.
Tone: Analytical
Relevance: 5/5
“I take a few right so I take some that are disease specific right so I take a pcsk9 inhibitor I take bidic acid uh I take an sglt2 inhibitor um and then I take at least one that is purely just uh based on the belief of its capacity and Juro protection which is rrap ayin and um and also the SG the sglt2 inhibitor I think is probably just broadly geroprotective.”
Main Takeaways:
- The speaker takes several supplements, some for disease-specific reasons and others for general health protection.
- Mentions taking a PCSK9 inhibitor, bidic acid, and an SGLT2 inhibitor.
- Rapamycin is taken based on its believed capacity for neuroprotection and general geroprotection.
Notes: Discussing personal supplement regimen
Tone: Informative
Relevance: 5/5
No comments yet.