blood glucose

No summary available for this substance.

Blood Glucose

Blood glucose, or blood sugar, refers to sugar that is transported through the bloodstream to supply energy to all the cells in our bodies. It is not a supplement but a critical health biomarker. Its levels in the body are primarily controlled by insulin—a hormone that moves glucose into the cells where it can be used for energy. Maintaining balanced blood glucose levels is important for overall health.

Category
Biomarker
Molecular Formula
C6H12O6
Mechanism of Action
Not applicable as blood glucose is a biomarker, not a bioactive compound or supplement. Insulin regulates its levels.
Evidence Grade
A

Other Names

  • Blood Sugar
  • Glycemia

Primary Benefits

  • Provides energy to cells
  • Regulates metabolic function

Recommended Dosage

Min 70 mg/dL
Max 130 mg/dL
Units mg/dL

Side Effects

  • Hypoglycemia (low blood glucose)
  • Hyperglycemia (high blood glucose)

Precautions

  • Diabetes
  • Insulin resistance
  • Hypoglycemia unawareness

Interactions

  • Certain medications can affect blood glucose levels

Key References

  • American Diabetes Association Standards of Medical Care in Diabetes
Sauna Use as an Exercise Mimetic for Heart and Healthspan
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“Insulin sensitivity, blood glucose levels, all those things were measured and they were the most insulin sensitive in the morning and the least insulin sensitive in the evening even though there's identical meals and that's because insulin sensitivity blood glucose all these genes that are regulating a variety of processes they're on a circadian rhythm meaning they're active during certain times in the day and the thing that starts that clock is the intake of food.”

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“throughout the day you want to keep your blood glucose steady without big spikes or dips using levels you can monitor how different types of foods and different food combinations as well as food timing and things like exercise combined to impact your blood glucose levels”

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Journal Club with Dr. Peter Attia | Metformin for Longevity & The Power of Belief Effects
Exploring Metformin's Potential for Longevity and Anti-Aging Benefits 1:19:32 0
“what I read was that berberine Poor Man's metformin could buffer blood glucose and in some ways make me feel less sick when ingesting all these calories in in many cases um spiking my my blood sugar and Insulin um because you're having ice cream and you know Etc and indeed it worked so if I took berberine and I don't recall the milligram count and then I ate you know 12 donuts I felt fine it was as if I had eaten one donut wow I felt sort of okay in my body and I felt much much better now”

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“it was like night and day difference in My My My fasting blood glucose my glucose disposal my postprandial levels”

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Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
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“the average blood glucose the lower it is the better you are and I say that even outside of diabetic range”

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Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
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“an average blood glucose of 100 on a CGM would be better than that of an average blood glucose of 115”

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“they would publish you know occasional studies about their blood glucose how it would affect their blood glucose their body fat and all these eventually when enough died over the next few years they came to very different conclusions”

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239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I)
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“that's your little energy boost system now if you had a little bit more um forward thinking you would say okay let me use that match to then actually just light a newspaper if you newspaper or something like that and if you're in the woods papers same thing you get fairly quick light not as fast as a match and it would give you some few minutes of energy doesn't matter what these numbers are it's just conceptual stuff here and that's great that's going to be carbohydrate right so carbohydrate is stored both in the cell as well as outside the cell in three major areas but in in the cell it's going to give you a lot more energy that is your most direct fast sty geometry is a little bit better but not much actually and so you're going to get a couple of moles of ATP per molecule of carbohydrate and that's not it's better but it's like you're sort of splitting hairs here a little bit um if that gets low you can now pull glucose out of the blood and for a little bit of terminology here glycogen in the tissue is what…”

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“I think average blood glucose is still the most important metric we care about um because that's the one for which we have the most data in other words we know all cause mortality data as as it relates to hemoglobin A1c hemoglobin A1c is a measurement that's used to impute average blood glucose so this is a very very close proxy when we can see average blood glucose on CGM even though it's not the same as measuring A1C it's very difficult to argue that knowing your average blood glucose on CGM and knowing your A1C aren't highly comparable and therefore by proxy the lower your average blood glucose on CGM the lower your all-cause mortality.”

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276 ‒ Special episode: Peter on longevity, supplements, protein, fasting, apoB, statins, & more
Longevity, Health Tools, Proactive Management: Nutrition, Exercise, Supplements, Genetic Insights 1:17:17 0
“The other metrics we look at of course are what's the standard deviation so you know all things equal do you have less variability in your glucose then more and and then finally and the least important I think is you know just what are the what's the you know how how big are the spikes you're seeing now in truth that becomes less important if the first two are reasonable if a person's average blood glucose is 98 milligrams per deciliter with a standard deviation of 16 milligrams per deciliter it doesn't really matter what kind of spikes they have because they're they're clearly not going to be too many.”

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“Monitoring your blood glucose levels allows you to run experiments to see how different foods impact you.”

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“Monitoring your blood glucose allows you to see how different foods impact you.”

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“Specifically what it does, is it, again, it binds to this complex one and reduces chemical energy in the body. And in reaction this mitohormesis is to amplify up mitochondria and make the body more sensitive to insulin and lower the blood glucose.”

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“And so you'd have this profile of regulating blood glucose. If this was tested, that seemed that you were just in a different place in your life, because they would start with young, healthy adults, and then all of a sudden, after one night of sleep loss, they would look like they were pre-diabetic.”

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Public health discussions on vital topics and practical recommendations. 1:02:20 0
“using Levels has helped me shape my entire schedule i now have more energy than ever and I sleep better than ever and I attribute that largely to understanding how different foods and behaviors impact my blood glucose”

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“nowadays there's all this excitement about walking I don't know if you you know I don't know how much time you spent on social media but like walking is the new thing for 2024 you know people discovered walking to lower you know postmeal blood glucose”

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“if you eat and in particular if you eat carbohydrates blood glucose goes up if you eat fats blood glucose goes up to a far less degree and if you eat proteins depending on the protein it'll eventually be broken down for fuel or assembled into amino acid chains for protein synthesis and repair of other tissues and bodily functions”

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“Zone 2 cardio that last anywhere from 30 minutes to an hour or something times more for your endurance athletes can create positive effects on blood sugar regulation such that you people can sit down and enjoy whatever it is the hot fudge Sunday or whatever the high sugar content food is and blood glucose management is so good your insulin sensitivity is so high which is a good thing that you can manage that blood glucose to the point where it doesn't really make you shaky it uh it doesn't disrupt you basically doing Zone to cardio for 30 to 60 Minutes 3 to four times a week makes your blood sugar really stable and that's an attractive thing for a variety of reasons.”

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“there's a prescription drug metformin which was developed as a treatment for diabetes and it works potently to reduce blood glucose it has dramatic effects in lowering blood glucose metformin involves changes to mitochondrial action in the liver that's its main way of depleting or reducing blood glucose and it does so through the so-called amk pathway and it increases insulin sensitivity overall metformin is a powerful drug”

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“the ketogenic diet has been shown in 22 studies to have a notable decrease on blood glucose and that is not surprising because you're the the essence of the of the ketogenic diet is that you're consuming very little or zero of the foods that promote big spikes in insulin and glucose”

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“So consuming anything that raises blood glucose, like grains, the amylopectin A of grains, raises blood glucose, which glycates small LDL particles. It also triggers the formation of small LDL particles.”

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“Every time blood glucose exceeds 100 but that becomes very important in collagen.”

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“two of the most obvious things that show up when I'm not well slept is you know higher blood glucose and higher blood pressure”

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“I'd say the worst outcome was using human growth hormone we were repeating a study that was done for thymus Rejuvenation so the gland responsible for the immune system so we did uh 100 days of human growth hormone 6 um 1.8 IU was the dose and we successfully changed my thymus fat fraction by uh seven years equivalent so I according to three MRIs we regenerated my thymus by seven years that was positive but it came at a pretty extreme cost I had intracranial pressure increase I had my blood glucose were messed up uh it was pretty disastrous for my body and so I don't think we would do hghh again I think we'd probably take a different approach maybe look at some peptides or something but we were trying to go after no one had um not no one only one group had tried to do thymus Rejuvenation it's a really hard one to get at and we wanted to take a stab of doing something hard and why was the thymus the primary organ you were focusing on with human growth hormone uh because well I guess we've been trying to rejuvenate all my organs…”

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“my reaction in terms of blood glucose response to different fruits is very variable”

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“It was messing with my lipids, blood glucose, resting heart rate was increased and I had some small tissue infections.”

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“restricting the feeding times it can be beneficial as well as keeping overall blood glucose lower can be beneficial”

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“berberine is kind of the Poor Man's metformin it's a tree bark extract that also dramatically lowers blood glucose”

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“so it took mice and then measured their blood glucose at different time of the day and in fact just like human blood Lookers our blood glucose fluctuates a little bit uh she saw that rhythm and then in every two hours or three hours on different days of course so you have the same dose of Metformin to mice and what she found was a different time of the day metformin had very dramatic change in glucose reducing ability”

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“berberine when ingested with carbohydrates in particular carbohydrates to have a lot of simple sugars definitely I know this because I measured my blood glucose I did the experiment allows you to flatten out your blood glucose response”

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“if you're taking a medication in addition to lower your blood glucose you could possibly go too low and yes it could be very very dangerous.”

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“if somebody is on insulin for example and their blood glucose goes down so what is the advice that we as a profession give? Well, eat something, right. It's like okay well sure at that one specific time yes I agree but in general if you're going down it means you're over medicated because I'm giving you this insulin to get your sugars low and your sugars are going too low so you're over medicated so you need to reduce the dose.”

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The Truth About Microplastics – Dr Rhonda Patrick
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“higher than you can basically be on the high end of the normal range for blood glucose levels so you're within the normal range but on the higher end right so you're not diabetic so you might think oh I don't have diabetes I'm fine I'm still within the normal range but there are studies showing that people on the high end of the normal range have increased atrophy in the hippocampus part of their brain that's involved in learning and memory and they have higher atrophy in the amygdala part of their brain that's involved in emotional regulation compared to people on the lower end have you know blood glucose levels in the lower end of the normal range.”

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“higher blood glucose levels are associated with increased like 54% Risk um increased risk for vascular dementia.”

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“you require insulin to move glucose out of the bloodstream into cells when you exercise you do not require insulin to move blood glucose out of the bloodstream into skeletal muscle tissue it can be insulin independent”

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Exercise & Nutrition Scientist: The Truth About Exercise On Your Period! Take These 4 Supplements!
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“for women it sits there the blood glucose sits there and when it starts being used use the hypothalamus is like okay where's the extra food that's coming in so we can keep going and countering the stress that's coming in”

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“after ovulation like I said progesterone comes up it's only produced if we ovulate because progesterone is produced from the breakdown of the housing of the egg progesterone like I said earlier will hold everything in the blood it will tell the body we need more blood glucose and we need that glucose to come to the endometrial lining we also need more amino acids so we're going to break down lean mass or I'm going to make this person crave more protein oriented Foods so that I can have amino acids to come in”

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“we have to look at things like heart rate variability we have to look at properly putting in intensity and resistance training to work with blood glucose levels to again attenuate some of the symptomology that comes with PCOS”

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Dr. Robert Lustig: How Sugar & Processed Foods Impact Your Health
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“If you're active, then you will clear glucose into muscle. Therefore, your blood glucose won't rise as much because it went into muscle and therefore your pancreas will put out less insulin because it doesn't have to clear as much from the bloodstream.”

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Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
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“I have heard that a short walk after a meal will reduce blood glucose in a way that's really dramatic, huge amount, 30-35% just taking a walk around the block after meal.”

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Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
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“let's talk about blood tests what what do you think are um the three to five things that basically everybody if they can should know about what circulating in their blood I'm I'm imagining LDL HDL this kind of thing I guess apob is a big uh favorite of our our friend Peter AA um fasting blood glucose continuous blood glucose postmeal Etc just kind of evaluating how exercise food Etc impacts blood glucose”

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“even having um too much bright light in a room while one is sleeping at night even dim light which is you know I don't want to scare people into thinking they have to sleep in complete darkness although an eye mask can be can be great um can alter uh morning blood glucose levels”

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Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
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“when people get the early night sleep of four to 5 hours but then don't get the dominating um you know last hour or two of sleep in the morning that resting blood glucose is is altered”

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“Deep sleep is very good at regulating your metabolic system and specifically your ability to control your blood sugar and your blood glucose.”

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“the main reason the beta cell is releasing the insulin is because blood glucose levels go up”

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The Insulin & Glucose Doctor: This Will Strip Your Fat Faster Than Anything!
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“insulin resistance insulin's having a harder time keeping the blood glucose levels in check anytime inflammation is up insulin resistance will be up as well”

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“Those individuals that are on a higher protein diet will seem to have higher blood glucose.”

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“It wasn't until I got on the Peloton or the exercise bike doing high intensity interval training that all of a sudden it normalized my blood glucose levels, even with the interrupted sleep.”

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“everything on our body runs on a clock and including our metabolism and um you know so so we're most insulin sensitive in the morning least sensitive insulin sensitive in the evening right so you know your blood glucose levels will go much higher with the same carbohydrate intake in the evening versus the morning even you know just calories are the same everything's the same”

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“We're going to look at how much muscle mass do you have, how much fat do you have in your liver, how much fat do you have around your organs, what do your insulin levels look like, what's your blood glucose look like, how high are your triglycerides.”

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“muscle mass plays makes sort of two appearances in longevity one appearance that muscle makes in longevity is that having a decent amount of muscle has secondary health effects for your rest of your system muscle is a glucose consumer and it keeps your blood glucose chronically lower than if you didn't have plenty of muscle”

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