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capsacin

No summary available for this substance.

Capsaicin

Capsaicin is the bioactive compound found in chili peppers, responsible for their characteristic heat. It is used in topical creams and lotions to relieve muscle or joint pain. It is also used orally for issues related to digestion such as upset stomach, diarrhea, and cramps.

Category
Pain Relief
Molecular Formula
C18H27NO3
Mechanism of Action
Capsaicin works by depleting or interfering with substance P, a chemical involved in transmitting pain impulses to the brain.
Evidence Grade
B

Other Names

  • Capsicum
  • Chili Pepper Extract
  • Red Pepper

Primary Benefits

  • Pain relief
  • Digestive health
  • Metabolism boost

Recommended Dosage

Topical 0.025% - 0.1% capsaicin cream applied 3-4 times daily
Oral 30-120mg daily, divided into 3 doses

Side Effects

  • Burning sensation
  • Redness
  • Skin irritation

Precautions

  • Avoid contact with eyes
  • Not recommended for pregnant or breastfeeding women
  • Avoid in people with liver or kidney disease

Interactions

  • May increase the risk of bleeding when taken with blood-thinning medications

Key References

  • Capsaicin for osteoarthritis pain. Prednisone and capsaicin cream for osteoarthritis pain. (2014). In P. J. Wiffen (Ed.), Cochrane Database of Systematic Reviews.
  • Mason, L., Moore, R. A., Derry, S., Edwards, J. E., & McQuay, H. J. (2004). Systematic review of topical capsaicin for the treatment of chronic pain. BMJ, 328(7446), 991.
Debunking The Internet’s Biggest Health Myths – Dr Karan Rajan
Holistic Insights on Gut Health, Nutrition, Sleep, and Well-being 2:22 0
“there's actually a couple of hormones uh one hormone in particular called kyin we can call it cckk for short and cckk actually delays gastric emptying and slows down how much your stomach empties into your small intestine so that hormone is increased if you eat foods that are high in fat or spicy foods so if you eat spicy foods the chemical capsacin in spicy foods or chilies actually increases the production of cck chosy ainin so there's more stomach content and there's more likelihood that you can burp or have reflux same with fatty foods that stimulate cck production more burping more reflux.”

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I don’t own or create any of this data—I just organize it and make it searchable, so always double-check with a real doctor before making any health decisions.