CBD
Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis, a plant with a rich history as a medicine going back thousands of years. Today the therapeutic properties of CBD are being tested and confirmed by scientists and doctors around the world. It is a safe, non-addictive substance, and is one of more than a hundred 'phytocannabinoids', which are unique to cannabis and endow the plant with its robust therapeutic profile.
- Category
- Phytocannabinoid
- Molecular Formula
- C21H30O2
- Mechanism of Action
- CBD acts on various molecular pathways, its most significant effect is the enhancement of endocannabinoid system by inhibiting the enzyme that breaks down endogenous cannabinoid anandamide. It also influences other types of receptors, like the serotonin and opioid receptors.
- Evidence Grade
- B
Other Names
Primary Benefits
- Pain relief
- Reduction of anxiety and depression
- Alleviation of cancer-related symptoms
- Neuroprotective properties
Recommended Dosage
| Minimum |
20mg per day |
| Maximum |
1500mg per day |
| Typical |
25-75mg per day |
Side Effects
- Fatigue
- Diarrhea
- Changes in appetite
- Changes in weight
Precautions
- People with liver disease should use CBD with caution
- Pregnant and breastfeeding women should avoid CBD
Interactions
- Warfarin
- Theophylline
- Clobazam
Key References
- Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and Cannabinoid Research, 2(1), 139–154.
- Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics : The Journal of the American Society for Experimental NeuroTherapeutics, 12(4), 825–836.
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