Clomid

No summary available for this substance.

Clomid

Clomid, also known as Clomiphene, is a medication used to treat infertility in women who do not ovulate, including polycystic ovary syndrome. It works by stimulating an increase in hormones that support the growth and release of a mature egg (ovulation).

Category
Fertility drug
Molecular Formula
C26H28ClNO
Mechanism of Action
Clomid works by binding to estrogen receptors in the hypothalamus, pituitary gland, ovary, endometrium, vagina, and cervix. It induces ovulation by causing the pituitary gland to release increased amounts of follicle stimulating hormone (FSH) and luteinizing hormone (LH).
Evidence Grade
A

Other Names

  • Clomiphene
  • Clomifene
  • Serophene
  • Milophene

Primary Benefits

  • Induces ovulation
  • Treats infertility in women
  • Treats polycystic ovary syndrome

Recommended Dosage

Adults Array

Side Effects

  • Hot flashes
  • Stomach discomfort
  • Breast tenderness
  • Blurred vision
  • Nausea
  • Ovarian enlargement

Precautions

  • Do not use if pregnant
  • Inform doctor of any liver disease
  • Inform doctor of any pituitary gland problems
  • May cause multiple births

Interactions

  • Gonadorelin
  • Other fertility drugs

Key References

  • https://www.ncbi.nlm.nih.gov/books/NBK549781/
  • https://www.webmd.com/drugs/2/drug-11204/clomid-oral/details
Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity
Optimizing Health and Longevity Through Nutrition, Hormones, and Exercise 1:39:08 0
“So, you know, a typical starting dose would be like 50 milligrams three times a week.”

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Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity
Optimizing Health and Longevity Through Nutrition, Hormones, and Exercise 1:39:15 0
“And if you do that, you'll notice, in most men, especially young men, FSH and LH goes up.”

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Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity
Optimizing Health and Longevity Through Nutrition, Hormones, and Exercise 1:40:29 0
“Sometimes, though not always, just a course of Clomid can wake him up, and he's back to making normal testosterone.”

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Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity
Optimizing Health and Longevity Through Nutrition, Hormones, and Exercise 1:40:43 0
“And estrogen and testosterone will increase in parallel.”

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Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity
Optimizing Health and Longevity Through Nutrition, Hormones, and Exercise 1:57:35 0
“So, it might be the case that you're going to need something upstream of that, like Clomid, to kick start it.”

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