Creatine monohydrate

No summary available for this substance.

Creatine monohydrate

Creatine monohydrate is a popular supplement among athletes and fitness enthusiasts for its ability to improve strength, muscle mass, and exercise performance. It is a substance that is found naturally in muscle cells and helps your muscles produce energy during heavy lifting or high-intensity exercise. Creatine monohydrate is the most researched form of creatine and has been shown to effectively increase muscle creatine levels.

Category
Sports and Performance Supplement
Molecular Formula
C4H11N3O3
Mechanism of Action
Creatine monohydrate increases the body's store of creatine phosphate, a compound that cells can use for rapid energy. It also aids in the production of adenosine triphosphate (ATP), which is used as energy by the muscles during high-intensity exercise.
Evidence Grade
A - Strong scientific evidence for this use

Other Names

  • Creatine
  • N-Amidinosarcosine
  • N-Methyl-N-guanylglycine
  • Methylglycocyamine

Primary Benefits

  • Enhanced muscle strength
  • Improved exercise performance
  • Increased muscle mass

Recommended Dosage

Initial Loading Dose 20g per day for 5-7 days
Maintenance Dose 3-5g per day

Side Effects

  • Weight gain
  • Muscle cramping
  • Nausea
  • Diarrhea

Precautions

  • Not recommended for individuals with kidney disease
  • May affect blood sugar levels, caution for diabetics
  • Pregnant and breastfeeding women should consult a healthcare provider before use

Interactions

  • May interact with caffeine and ephedra
  • May affect drugs that harm the kidneys

Key References

  • Buford, T. W., Kreider, R. B., Stout, J. R., Greenwood, M., Campbell, B., Spano, M., ... & Antonio, J. (2007). International Society of Sports Nutrition position stand: creatine supplementation and exercise. Journal of the International Society of Sports Nutrition, 4(1), 1-8.
  • Hultman, E., Söderlund, K., Timmons, J. A., Cederblad, G., & Greenhaff, P. L. (1996). Muscle creatine loading in men. Journal of applied physiology, 81(1), 232-237.
The Optimal Creatine Protocol for Strength, Brain, and Longevity | Darren Candow, PhD
Maximizing Health Benefits with Creatine for Strength, Brain, and Longevity 1:16:37 0
“creatine monohydrate is that still the gold standard for supplementing with creatine if so why”

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The Optimal Creatine Protocol for Strength, Brain, and Longevity | Darren Candow, PhD
Maximizing Health Benefits with Creatine for Strength, Brain, and Longevity 1:17:40 0
“no other creatine has ever gotten into the cell and had Superior effects”

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Breaking Bad Habits & Living Your Best Life – Dr Andrew Huberman (4K)
Optimizing Health and Functionality Through Sleep and Rhythm Management 3:20:50 0
“I take creatine monohydrate I have since I was 17 years old um at that time everyone said it was going to blow out your kidneys or whatever but anyway I read about it in a uh mm2000 issue for those of you that remember I was like well this stuff really works turns out doesn't destroy your kidneys okay it's also good for cognition it turns out.”

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Muscle Expert (Jeff Cavaliere): You Need To Know This About Creatine! Melt Belly Fat With 1 Change!
Understanding Fitness: Diet, Exercise, Mental Health, and Long-term Well-being 1:52:53 0
“The two that rank at the very very top of the list are going to be creatine monohydrate or creat any form of creatine. There's different forms of creatine. We can get into those, but creatine and a protein powder.”

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Muscle Expert (Jeff Cavaliere): You Need To Know This About Creatine! Melt Belly Fat With 1 Change!
Understanding Fitness: Diet, Exercise, Mental Health, and Long-term Well-being 1:58:50 0
“The creatine monohydrate is usually taken at a higher dosage. And now there's some new research coming out that states that I used to think that it was just five grams for everybody, but now they're finding that people that are like upwards of 200 lb or more, they might benefit from like 8, nine, 10 grams per day.”

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Dr. Peter Attia: Supplements for Longevity & Their Efficacy
Supplements, Lifestyle, and Strategies for Longevity and Optimal Health 2:17:30 0
“I take creatine monohydrate five grams a day”

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How to Exercise & Eat for Optimal Health & Longevity | Dr. Gabrielle Lyon
Optimizing Health and Longevity Through Nutrition, Exercise, and Supplements 2:11:25 0
“I and many other people supplement with 5 to 10 grams of creatine monohydrate per day.”

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