curcumoids

Curcuminoids

Curcuminoids are natural phenols derived from the rhizome of Curcuma longa (turmeric). They are the principal bioactive constituents of turmeric, providing its characteristic yellow color and a range of potential health benefits. The three main compounds in this group are curcumin, demethoxycurcumin, and bisdemethoxycurcumin.

Category

Phytochemicals

Molecular Formula

C21H20O6

Mechanism of Action

Curcuminoids exert their effects mainly through anti-inflammatory and antioxidant mechanisms. They inhibit nuclear factor kappa-B (NF-kB), a key regulator of the inflammatory response, and scavenge free radicals, reducing oxidative stress.

Evidence Grade

A for anti-inflammatory and antioxidant effects, B for other potential benefits

Other Names

• Turmeric extract
• Curcuma longa extract

Primary Benefits

• Anti-inflammatory
• Antioxidant
• May improve brain function
• Potentially reduces heart disease risk
• May aid in preventing and treating Alzheimer's
• May help with arthritis

Recommended Dosage

Side Effects

• Nausea
• Diarrhea
• Headache
• Yellow stool

Precautions

• Pregnancy and breastfeeding
• Gallbladder disease
• Bleeding disorders
• Diabetes
• Gastroesophageal reflux disease (GERD)
• Hormone-sensitive conditions

Interactions

• Anticoagulant / Antiplatelet drugs
• Drugs for diabetes
• Drugs metabolized by liver

Key References

• Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41(1):40-59.
• Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595:105-125.