DHEA

No summary available for this substance.

DHEA

Dehydroepiandrosterone (DHEA) is a hormone that is naturally produced by the adrenal glands and the brain. It serves as a precursor to male and female sex hormones, including estrogen and testosterone. DHEA levels naturally decrease with age, and this decrease has been associated with a range of age-related conditions, leading to its study and use as a dietary supplement.

Category
Hormone
Molecular Formula
C19H28O2
Mechanism of Action
DHEA primarily functions as a precursor hormone—meaning it is involved in the production of other hormones, mainly sex hormones like estrogen and testosterone. It can affect immune function, brain function, bone metabolism, energy metabolism, the growth and differentiation of cells, and the regulation of mood.
Evidence Grade
C

Other Names

  • Prasterone
  • Androstenolone

Primary Benefits

  • May improve aging skin
  • Might help in treating depression
  • Could improve sexual function
  • Possibly helps in managing osteoporosis

Recommended Dosage

Adults 5-50 mg per day

Side Effects

  • Acne
  • Hair loss
  • Stomach upset
  • High blood pressure

Precautions

  • Avoid during pregnancy or breastfeeding
  • Not recommended for people with hormone-sensitive conditions
  • People with liver disease should use with caution

Interactions

  • Estrogen
  • Testosterone
  • Insulin
  • Corticosteroids

Key References

  • National Institutes of Health (NIH)
  • Mayo Clinic
#123–Joan Mannick & Nir Barzilai: Rapamycin and metformin—longevity, immune enhancement, & COVID-19
Enhancing Longevity and Health with Immune-Boosting Substances Research Insights 1:49:11 0
“they took patients and gave them a growth hormone, metformin and dhea”

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Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity | Lifespan w Dr. David Sinclair #5
Benefits and Risks of Hormone Therapies for Longevity and Health 52:46 0
“He uses growth hormone, which is known to raise blood sugar levels, but then he realized if he could include DHEA, a hormone that is depleted during aging, as well as Metformin, he could mitigate the negative effects of growth hormone.”

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Gary Brecka: The TRUTH About Biohacking, Light Therapy, and Nutrients
Optimizing Health: Lifestyle, Nutrition, Sleep, Exercise, and Social Connections 1:03:56 0
“you restore the cholesterol you can restore the hormones very often you restore the DHEA level you restore the hormones very often you get sex hormone binding protein out of the way by taking a mineral called Boron”

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Dr. Greg Fahy: Thymus Regeneration & Boosting The Immune System For Longevity
Boosting Immune System and Thymus Regeneration for Longevity Insights 11:18 0
“what if the hidden sleeper function of DHA was actually to prevent specifically hyperinsulinemia induced by growth hormone”

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Dr. Greg Fahy: Thymus Regeneration & Boosting The Immune System For Longevity
Boosting Immune System and Thymus Regeneration for Longevity Insights 13:43 0
“DHEA helps to block the lipolysis of the actually DHA contributes to lipolysis itself but also turns over the lipid but burns the fatty acids and has other effects that mitigate the effects of the fatty increase”

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Dr. Greg Fahy: Thymus Regeneration & Boosting The Immune System For Longevity
Boosting Immune System and Thymus Regeneration for Longevity Insights 1:18:22 0
“growth hormone metformin d haa that's tried and true that seems to be working”

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