Doxycycline
Doxycycline is a broad-spectrum antibiotic from the tetracycline class. It is synthetic, but its structure is derived from naturally occurring tetracycline antibiotics. It works by inhibiting the protein synthesis of bacteria, thus preventing their growth and multiplication. It is used to treat a variety of bacterial infections, including those caused by bacteria, such as pneumonia and other respiratory tract infections; Lyme disease; acne; infections of skin, genital, and urinary systems; and anthrax (after inhalational exposure). It is also used to prevent malaria.
- Category
- Antibiotic
- Molecular Formula
- C22H24N2O8
- Mechanism of Action
- Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thus preventing the addition of amino acids to the growing peptide chain.
- Evidence Grade
- A
Other Names
- Vibramycin
- Oracea
- Monodox
- Adoxa
Primary Benefits
- Treats bacterial infections
- Prevents malaria
- Treats acne
Recommended Dosage
| Adult |
100-200 mg per day in one or two doses |
| Children |
Depends on body weight, typically 2-4 mg/kg per day in one or two doses |
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Skin rash
- Photosensitivity
Precautions
- Not recommended during pregnancy and breastfeeding
- Avoidance of sunlight and UV light
- Not recommended for children under 8
Interactions
- Antacids
- Iron supplements
- Calcium supplements
- Warfarin
- Penicillin
Key References
- https://www.ncbi.nlm.nih.gov/books/NBK470271/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201790/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1744575/
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