Fish oil

No summary available for this substance.

Fish oil

Fish oil is derived from the tissues of oily fish and is a rich source of omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These fatty acids are essential nutrients that are important in preventing and managing heart disease. Fish oil is often used as a supplement for its anti-inflammatory properties and benefits for heart health.

Category
Dietary supplement
Molecular Formula
Variable, due to different combinations of fatty acids
Mechanism of Action
Omega-3 fatty acids in fish oil have anti-inflammatory effects and also affect heart health by reducing triglycerides, blood pressure, and the risk of blood clots.
Evidence Grade
A

Other Names

  • Omega-3 fatty acids
  • EPA/DHA

Primary Benefits

  • Supports heart health
  • May help reduce inflammation
  • Potential benefits for mental health

Recommended Dosage

Adults 1-2 grams per day
Children Consult a healthcare professional

Side Effects

  • Fishy aftertaste
  • Nausea
  • Diarrhea
  • Heartburn

Precautions

  • People on blood thinners should consult with a healthcare provider
  • People with seafood allergies should avoid fish oil

Interactions

  • May interact with blood thinners
  • May interact with blood pressure medication

Key References

  • https://www.mayoclinic.org/drugs-supplements-fish-oil/art-20364810
  • https://www.hsph.harvard.edu/nutritionsource/fish/
How to Optimize Female Hormone Health for Vitality & Longevity | Dr. Sara Gottfried
Optimizing Women's Health: Hormones, Nutrition, Exercise, and Genetics Insights 1:38:54 0
“phosphatidylserine PS for short fish oil also more modestly reduces cortisol”

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How to Optimize Female Hormone Health for Vitality & Longevity | Dr. Sara Gottfried
Optimizing Women's Health: Hormones, Nutrition, Exercise, and Genetics Insights 1:52:57 0
“I would say fish oil yes, I think a thousand milligrams as a general recommendation is good but I also have a food first philosophy so my preference would be that they're having salmon or some kind of Smash fish and they're getting that as the primary source of their Omega-3s.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 3:07 0
“Fish oil is from an animal but it's liquid, so it's got this kind of cuts across and so he said well let's see what high fish oil diet does to cholesterol levels.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 3:19 0
“we had three groups you know saturated fat, control, polyunsaturated fat and fish oil and that's when we were doing our very high dose you know drink a half a cup of salmon oil every day for our volunteers.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 3:44 0
“that's when we discovered that it lowered triglycerides because we weren't looking for that we were looking for cholesterol effects.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 43:38 0
“you might want to go down to your local drugstore and pick off a bottle of fish oil and just take it and don't tell anybody or at the very least you can do your fish intake or start eating more fish”

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276 ‒ Special episode: Peter on longevity, supplements, protein, fasting, apoB, statins, & more
Longevity, Health Tools, Proactive Management: Nutrition, Exercise, Supplements, Genetic Insights 27:59 0
“I take EPA and DHA so I take fish oil... by taking four of these capsules a day I'm taking roughly 2 grams of EPA a day and probably a gram and a half of DHA.”

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276 ‒ Special episode: Peter on longevity, supplements, protein, fasting, apoB, statins, & more
Longevity, Health Tools, Proactive Management: Nutrition, Exercise, Supplements, Genetic Insights 38:46 0
“I was taking a different brand of fish oil before... I had used Carlson's in the past had switched to Nordic Naturals now I've switched back to this I find it to be just a slightly more robust product.”

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Rhonda Patrick at Orthomolecular Medicine Congress in Bussum, Netherlands (Keynote Oct. 3rd, 2015)
Optimizing Health Through Micronutrients: Key Role in Disease Prevention 49:12 0
“Most of the studies that I cite in the paper are using high doses of Omega-3 of fish oil and they're using between 3 to six grams a day.”

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Leading Cardiologist: Your Doctor Is WRONG About Cholesterol | Dr. William Davis
Challenging Health Myths: Nutrition, Heart Health, and Gut Microbiome Insights 35:47 0
“When they... process fish oil, they process it in ethanol and alcohol, and it breaks off those three fatty acids.”

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Leading Cardiologist: Your Doctor Is WRONG About Cholesterol | Dr. William Davis
Challenging Health Myths: Nutrition, Heart Health, and Gut Microbiome Insights 36:02 0
“But you can also buy fish oil where the triglyceride form is reconstituted onto a glycerol backbone once again.”

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Leading Cardiologist: Your Doctor Is WRONG About Cholesterol | Dr. William Davis
Challenging Health Myths: Nutrition, Heart Health, and Gut Microbiome Insights 44:13 0
“You take fish oil, and it reduces fibrinogen. That's not blood thinning, that's correction of an abnormality, but it's interpreted as blood thinning.”

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Leading Cardiologist: Your Doctor Is WRONG About Cholesterol | Dr. William Davis
Challenging Health Myths: Nutrition, Heart Health, and Gut Microbiome Insights 45:37 0
“krill oil is 40 times more potent than fish oil. That is complete nonsense.”

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The Root Cause of Metabolic Dysfunction w/ Dr. Casey Means
Understanding Metabolic Health: Risks, Dysfunction, and Dietary Recommendations 1:03:23 0
“if we ate seven tablespoons fish oil per day that might be a problem for humans right there are actually studies in Eskimos who eat lots of fish that like there we can exceed the amount of Omega-3s that we want it can lead to potential clotting issues and maybe even hemorrhagic strokes”

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REVERSE AGING: What To Eat & When To Eat For LONGEVITY | David Sinclair
Enhance Health, Longevity, and Disease Prevention with Lifestyle Choices 1:57:52 0
“i switched my supplement from a fish oil to one that has more oleic acid yeah and oleic acid is the one that activates sort one and you find it in olive oil and avocados”

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The Cancer Expert: “This Common Food Is Making Cancer Worse!”
Cancer Prevention Through Lifestyle Changes and Metabolic Health Strategies 55:46 0
“she cut the calories of the dog, she got uh pollic fish oil, raw eggs and cut all the calories everything was all natural for this dog.”

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The Cancer Expert: “This Common Food Is Making Cancer Worse!”
Cancer Prevention Through Lifestyle Changes and Metabolic Health Strategies 59:09 0
“he's on English telev or things with all of his paleo diet which actually a low very low carbohydrate diet he had the avocados there he had the fish oil there he had this different stuff.”

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Is This the Missing Longevity Nutrient?
The Vital Longevity Nutrient Revealed for Optimal Health Benefits 44:02 0
“I love fish. There's so much um there's so many studies been showing that the more fish we eat, if we eat two to four servings a week that the better our health.”

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Is This the Missing Longevity Nutrient?
The Vital Longevity Nutrient Revealed for Optimal Health Benefits 46:50 0
“So, if you're you like leave the oil out of the fish oil supplements, they can get rancid. It's shipped via Amazon and sits out in the summer heat for 90 degrees on your doorstep for two days while you're on vacation. you come back and put that in your fridge, it's still probably pretty damaged.”

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Dr. Peter Attia: Supplements for Longevity & Their Efficacy
Supplements, Lifestyle, and Strategies for Longevity and Optimal Health 2:12:28 0
“I take EPA and DHA in the form of liquid or capsule fish oil capsules”

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How to Exercise & Eat for Optimal Health & Longevity | Dr. Gabrielle Lyon
Optimizing Health and Longevity Through Nutrition, Exercise, and Supplements 1:36:08 0
“fish oil omega-3 fatty acids there's a lot of research around that and I think that it's a it's a positive it's not only a positive for brain function but it seems to have a unique anabolic effect”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 38:44 0
“Fish oil supplements, if you get a high quality one, it's in a triglyceride form.”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 46:11 0
“The International Fish Oil Standards, IFSO, they have a website where they do third-party testing of a ton of different fish oil supplements from around the world, and they measure the concentration of the omega-3 fatty acids in the actual supplement, because nothing is ever what it says on the bottle, and then they also measure contaminants, so mercury, PCBs, dioxins, things that you'd find potentially in fish that are harmful to humans, and they also measure mercury and then oxidized fatty acids.”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 54:16 0
“So two grams or more is the magic number, I think.”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 54:27 0
“I personally think it is one of the most powerful, anti-inflammatory things, dietary lifestyle, things that we can get easily, relatively easily, that is going to powerfully modulate the way you think, the way you feel, and the way you age.”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 56:13 0
“And he's measuring the Omega-3 Index in people, and then looking at their mortality risk, for example, or their cardiovascular disease risk.”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 56:29 0
“Japan, by contrast, has an Omega-3 Index of around 10 to 11%. Big difference there. And they also have about a five-year increased life expectancy compared to people in the US.”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 1:00:41 0
“But it seems to me that these animals have to either be taking fish oil or eat plants that are very rich in omega-3s in order for the meat to actually contain sufficient omega-3s.”

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How Vitamin D, Omega-3s, & Exercise May Increase Longevity | Dr. Rhonda Patrick
Essential Insights for Health and Longevity Through Diet and Lifestyle 28:11 0
“but they were also eating a lot of fish, supplementing with fish oil.”

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How Vitamin D, Omega-3s, & Exercise May Increase Longevity | Dr. Rhonda Patrick
Essential Insights for Health and Longevity Through Diet and Lifestyle 37:17 0
“There are third-party testing sites that will test omega-3 oxidation status, and they also test PCBs, mercury, and everything. I think the best one that I use is called the International Fish Oil Standards website.”

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The Most Important Daily Habits For Health & Longevity – Dr Rhonda Patrick (4K)
Essential Omega-3 for Health, Longevity, and Disease Prevention Strategies 7:56 0
“I think choosing omega-3 supplement is um we actually have a lot of data now days and we have access to that data quite easily because there's a lot of third party testing sites that go out and they just randomly get fish oil supplements off the grocery store shelves and they say I'm going to take this supplement I'm going to measure important things”

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