Fluoroquinolones
Fluoroquinolones are a type of broad-spectrum antibiotics that are commonly used in the treatment of bacterial infections. They are particularly effective against Gram-negative bacteria, including Pseudomonas aeruginosa. They work by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair and recombination.
- Category
- Antibiotics
- Molecular Formula
- Varies with specific compound
- Mechanism of Action
- Inhibition of DNA gyrase and topoisomerase IV
- Evidence Grade
- A
Other Names
- Quinolones
- Ciprofloxacin
- Levofloxacin
- Moxifloxacin
Primary Benefits
- Effective against a wide range of bacterial infections
- Can be used to treat drug-resistant bacteria
Recommended Dosage
| Adults |
Varies based on specific infection and individual health status |
| Children |
Not typically recommended for children or adolescents |
Side Effects
- Nausea
- Diarrhea
- Headache
- Dizziness
- Tendon damage
- Nervous system issues
Precautions
- Not recommended for pregnant or breastfeeding women
- Should not be used in individuals with a history of tendon disorders
- Should be used with caution in individuals with a history of seizure disorders
Interactions
- Antacids
- Dairy products
- Multivitamins containing zinc or iron
- Certain heart medications
Key References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185021/
- https://www.mayoclinic.org/drugs-supplements/fluoroquinolone-oral-route-intravenous-route-injection-route/description/drg-20072288
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