Fusobacterium nucleatum
Fusobacterium nucleatum is a gram-negative, anaerobic, oral bacterium, part of the human oral microbiota. It is not a supplement, but rather a bacterium known to be associated with periodontal disease, adverse pregnancy outcomes, and is implicated in various forms of cancer.
- Category
- Microorganism
- Molecular Formula
- Not applicable
- Mechanism of Action
- F. nucleatum can adhere to and invade host epithelial and endothelial cells, and modulate host immune responses, thereby contributing to disease progression.
- Evidence Grade
- Not applicable
Other Names
Primary Benefits
- None - it is generally considered pathogenic
Recommended Dosage
| Minimum |
Not applicable |
| Maximum |
Not applicable |
| Average |
Not applicable |
Side Effects
- Periodontal disease
- Adverse pregnancy outcomes
- Gastrointestinal disorders
- Potential carcinogenic effects
Precautions
- Not applicable - it is not a supplement
Interactions
- Interactions with other oral bacteria and the host immune system
Key References
- Han, Y.W., 'Fusobacterium nucleatum: a commensal-turned pathogen', Current Opinion in Microbiology, 2015
- Gholizadeh, P., et al., 'Role of oral microbiome on oral cancers, a review', Biomedicine & Pharmacotherapy, 2016
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