GLP-1 agonists

No summary available for this substance.

GLP-1 agonists

GLP-1 (Glucagon-like peptide-1) agonists are a group of medications that mimic the actions of natural GLP-1. GLP-1 is an incretin hormone that stimulates insulin secretion and inhibits glucagon secretion, both of which can reduce blood glucose levels. GLP-1 agonists are commonly used in the treatment of type 2 diabetes.

Category
Diabetes medication
Molecular Formula
Varies depending on the specific GLP-1 agonist
Mechanism of Action
GLP-1 agonists bind to the GLP-1 receptor, which leads to an increase in insulin secretion, a decrease in glucagon secretion, a decrease in hepatic glucose production, and a slow down of gastric emptying.
Evidence Grade
A

Other Names

  • Glucagon-like peptide-1 receptor agonists
  • Incretin mimetics

Primary Benefits

  • Lowering blood glucose levels
  • Weight loss
  • Cardioprotective effects

Recommended Dosage

Adults Varies depending on the specific GLP-1 agonist used and individual patient characteristics
Children Not typically recommended for children

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Potential risk of pancreatitis

Precautions

  • Should be used with caution in patients with a history of pancreatitis
  • Not recommended for patients with severe gastroparesis
  • Should not be used in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Interactions

  • May have interactions with other antidiabetic drugs
  • May affect the absorption of orally administered medications due to slowing of gastric emptying

Key References

  • Trujillo, JM, Nuffer, W, Ellis, SL. GLP-1 receptor agonists: a review of head-to-head clinical studies. Ther Adv Endocrinol Metab. 2015;6(1):19-28.
  • Nauck MA, Meier JJ. Incretin hormones: Their role in health and disease. Diabetes Obes Metab. 2018;20 Suppl 1:5-21.
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver
Exploring Peptides, Hormones, and Therapies for Health and Wellness 1:37:34 0
“The glp1 Agonist FDA approved drug”

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Longevity Supplements, Predatory Experts & Continuous Glucose Monitors | Dr. Eric Topol
Exploring Aging, Genetics, Disease Prevention, Nutrition, and Lifestyle Factors 31:08 0
“So we have multiple biomarkers which this one is the best and and we also for example the ompic drugs the glip one drugs they're in trials now in thin people to prevent Alzheimer's if one of those hits which it's certainly possible given all the other data we've seen right then you have a drug a disease modifying drug for Alzheimer's and by the way uh they have potent anti-inflammatory effects in the brain.”

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The Anti-Obesity Doctor: If You Don’t Exercise, This Is What’s Happening To You! – Gabrielle Lyon
The Importance of Resistance Training for Longevity and Health 1:10:58 0
“glp1 Agonist which improve satiation so like a zenek is a GP one Agonist which makes you less hungry yes dietary protein in part works on that same kind of mechanism also releases glp which makes me less hungry yes okay improve your satiation okay dietary protein we know can help regulate hunger can also maintain blood sugar right if you have carbohydrates in in check not a very efficient way but your body can generate glucose from dietary protein”

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335 ‒ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding
Strategies for Building Lean Muscle, Hormone Balance, and Nutrition 2:59:53 0
“the only thing that the glps eliminate as a category of problem is the hunger Drive they eliminate it but they do a great job reduce it substantially”

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335 ‒ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding
Strategies for Building Lean Muscle, Hormone Balance, and Nutrition 3:01:44 0
“if you now have a solution to the hard dieting problem in which you can actually do much better job with less input that doesn't mean you're on the couch eating Cheetos though it could if you choose”

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Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity
Optimizing Health and Longevity Through Nutrition, Hormones, and Exercise 2:40:53 0
“People are talking about this as the blockbuster obesity drug.”

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