glucoraphanin

No summary available for this substance.

Glucoraphanin

Glucoraphanin is a glucosinolate compound found in cruciferous vegetables, particularly broccoli and its sprouts. It is a precursor to sulforaphane, a bioactive compound known for its antioxidant, anti-inflammatory, and anticarcinogenic properties.

Category
Phytochemical
Molecular Formula
C12H23NO10S3
Mechanism of Action
Glucoraphanin is converted into sulforaphane by the enzyme myrosinase when the plant material is chewed or damaged. Sulforaphane then activates the Nrf2 pathway, enhancing the body's antioxidant response and providing protection from oxidative stress.
Evidence Grade
B - Moderate evidence for health benefits

Other Names

  • 4-methylsulfinylbutyl glucosinolate

Primary Benefits

  • Antioxidant effects
  • Anti-inflammatory effects
  • Potential anticarcinogenic properties

Recommended Dosage

Adults There is no officially recommended dosage, but studies often use doses ranging from 30 to 60 mg of sulforaphane (derived from glucoraphanin) per day.

Side Effects

  • Gastrointestinal discomfort
  • Bloating
  • Gas

Precautions

  • Pregnant and breastfeeding women should consult a healthcare professional before use
  • People with thyroid conditions should use caution

Interactions

  • Thyroid medications

Key References

  • Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A. 1997
  • Liu H, Talalay P. Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention. Proc Natl Acad Sci U S A. 2013
Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More
Health Benefits of Cruciferous Vegetables and Sulforaphane for Well-being. 11:17 0
“sulforaphane and its precursor glucoraphanin can actually significantly increase the excretion of benzene”

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Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More
Health Benefits of Cruciferous Vegetables and Sulforaphane for Well-being. 42:55 0
“broccoli sprouts topped the list as a source of glucoraphanin which is why we talk today a lot about the young sprouts of these plants.”

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The Truth About Microplastics – Dr Rhonda Patrick
Understanding Microplastics and Toxin Exposure in Everyday Health and Environment 1:06:00 0
“the major dietary activator of this system is a compound called sulfurane which is something that you can produce when you eat cruciferous vegetables like broccoli broccoli um is a good source actually the younger plant broccoli Sprouts have a hundred times more of the precursor to make sulfur called glucoraphenin um so you basically this suhane compound is made when the plant is like broken so when you bite it chew it right that's when you start to make the suhane so broccoli Sprouts have a really really high concentration of that precursor.”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 22:17 0
“So the sulforaphane is formed from a compound called glucoraphanin, which is in the broccoli, and the enzyme that converted into sulforaphane is myrosinase, and it's heat sensitive.”

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