glutamine

No summary available for this substance.

Glutamine

Glutamine is an important amino acid with many functions in the body. It is a critical part of the immune system and has a special role in intestinal health. Glutamine is found in many foods and is also often taken as a supplement.

Category
Amino Acid
Molecular Formula
C5H10N2O3
Mechanism of Action
Glutamine serves as a substrate for the synthesis of nucleotides, proteins, and amino sugars. It also plays a role in maintaining the integrity of the intestinal mucosa and preserving lean body mass.
Evidence Grade
B

Other Names

  • L-Glutamine
  • Gln
  • Q

Primary Benefits

  • Supports immune system
  • Promotes gut and brain health
  • Enhances muscle growth and exercise performance
  • May help in weight loss

Recommended Dosage

Adults 5 to 30 grams per day
Children Consult a healthcare professional

Side Effects

  • Bloating
  • Stomach discomfort
  • Cough or hoarseness
  • Frequent urge to defecate

Precautions

  • Avoid if you have liver disease
  • Avoid if you have a history of seizures
  • Use with caution if you are pregnant or breastfeeding

Interactions

  • Interacts with medications like Lactulose, chemotherapy drugs, and anti-seizure medications

Key References

  • Lacey, J. M., & Wilmore, D. W. (1990). Is glutamine a conditionally essential amino acid? Nutrition reviews, 48(8), 297-309.
  • Rao, R., & Samak, G. (2012). Role of glutamine in protection of intestinal epithelial tight junctions. Journal of epithelial biology & pharmacology, 5(Suppl 1-M7), 47.
  • Bowtell, J. L., Gelly, K., Jackman, M. L., Patel, A., Simeoni, M., & Rennie, M. J. (1999). Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. Journal of Applied Physiology, 86(6), 1770-1777.
The Optimal Creatine Protocol for Strength, Brain, and Longevity | Darren Candow, PhD
Maximizing Health Benefits with Creatine for Strength, Brain, and Longevity 57:13 0
“I wonder if there's any um has anyone ever looked at you know creatine's role in helping prevent infectious you know disease or respiratory illness fighting off pathogens like just anecdotally uh I supplement with glutamine my 5 grams of it's about 5.6 grams of glutamine I take a day and with creatine five grams of creatine and it has made a insanely big difference in my susceptibility to respiratory illness”

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Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis
Optimizing Health and Longevity Through Nutrition, Fasting, and Exercise 28:29 0
“In animal studies, you showed that because of the fasting lowers glucose levels, and... Like you mentioned, cancer cells love glucose, that's called the Warburg effect, where they're predominantly using glucose, of course, they also use glutamine and amino acids.”

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Everything You Need To Know About Supplements, Cardio, and Metabolism | Dr. Eric Trexler
Insights on Managing Metabolism, Weight, Diet, Exercise, and Sleep 1:58:03 0
“Glutamine fall into tier four um for the purposes of getting you jacked and shredded not intestinal Health right I was going to say for clinical applications talk to a doctor dietitian a real doctor.”

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You’re Eating Too Much Sugar! – You May Never Eat It Again After Watching This | Dr. Robert Lustig
Impacts of Sugar Consumption on Health and Chronic Diseases Prevention 1:37:02 0
“sugar inhibits an enzyme in the brain in astrocytes called glutamine synthetase.”

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The Cancer Expert: “This Common Food Is Making Cancer Worse!”
Cancer Prevention Through Lifestyle Changes and Metabolic Health Strategies 17:32 0
“a solution to the cancer problem to manage cancer without toxicity is to simultaneously restrict the two fuels that are needed to drive this disregulated growth while transitioning the whole body off to a fuel that the tumor cells can't use which is fatty acids and Ketone bodies.”

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The Cancer Expert: “This Common Food Is Making Cancer Worse!”
Cancer Prevention Through Lifestyle Changes and Metabolic Health Strategies 24:42 0
“exercise lowers blood sugar you know you and and also lowers glutamine so uh the two fuels that are driving uh now we can't completely remove glutamine by exercise that's for sure um but we my my late good friend George kahill published some papers on showing how exercise could actually lower uh glutamine availability so it's a it's a little bit of a push but you're also when you exercise you're burning and you're not eating a lot of carbs your mitochondria burning ketones and the oxygenation from all the exercise is keeping those mitochondria super healthy at their highest level of Energy Efficiency so exercise you're building muscle as well aren't you yeah you're building well you can build muscle but you're certainly getting aerobic exercise to oxygen is coming in and you're burning ketones which I already told you is a super fuel so your body is super healthy”

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The Cancer Expert: “This Common Food Is Making Cancer Worse!”
Cancer Prevention Through Lifestyle Changes and Metabolic Health Strategies 48:03 0
“with metabolic therapy you can use it as both a prevention and a treatment it's just that with a treatment we bring in some more drugs to Target the glutamine we don't do that on the prevention side”

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The Cancer Expert: “This Common Food Is Making Cancer Worse!”
Cancer Prevention Through Lifestyle Changes and Metabolic Health Strategies 1:04:01 0
“he didn't take radiation or chemo yeah and he brought his glucose Ketone index down to the 2.0 Zone and kept it low and he took some supplements and a few things here and there but he wasn't really targeting the glutamine like we thought it with like we we thought we we found now certain parasite medications will be effective in targeting glutamine so we're doing all non-toxic strategies to manage cancer”

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Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
Transform health by improving metabolism, hormone regulation, blood sugar control. 1:45:12 0
“protein of course Very potently stimulates these nutrient receptor cells and specifically like veiling and glutamine seem to have a potent stimulatory effect on glp1 so you're find that and like meat and turkey and eggs and things like that”

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Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
Transform health by improving metabolism, hormone regulation, blood sugar control. 1:48:14 0
“other things for gp1 secretion the thids also Fiers has been shown specific amino acids so high protein foods things that involve a lot of veine and glutamine uh green tea and specifically the uh elic the EC um ecgc that uh is one of the compounds in green tea that's been shown to stimulate glp1 curcumin”

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