Ibogaine
Ibogaine is a naturally occurring psychoactive substance found in plants in the Apocynaceae family such as Tabernanthe iboga. It has been used in traditional African medicine for centuries for various purposes, including rites of passage. More recently, it has been explored as a potential therapy for substance use disorders, though its use is controversial due to its psychoactive properties and safety concerns.
- Category
- Psychoactive substance
- Molecular Formula
- C20H26N2O
- Mechanism of Action
- Ibogaine is a non-competitive antagonist at α3β4 nicotinic acetylcholine receptors and has been found to promote the release of glutamate. It also inhibits the reuptake of serotonin, dopamine, and norepinephrine, contributing to its psychoactive effects.
- Evidence Grade
- C
Other Names
- Iboga
- Tabernanthe iboga extract
Primary Benefits
- Potential treatment for substance use disorders
Recommended Dosage
| Low Dose |
5-10 mg/kg |
| Average Dose |
15-20 mg/kg |
| High Dose |
25-30 mg/kg |
Side Effects
- Nausea
- Vomiting
- Ataxia
- Hallucinations
- Heart rhythm disturbances
Precautions
- Not recommended for people with heart conditions
- Not recommended for pregnant or breastfeeding women
- Not recommended for individuals with psychiatric disorders
Interactions
- Interacts negatively with other psychoactive substances
- Interacts negatively with medications affecting heart rhythm
Key References
- Alper, K.R., Lotsof, H.S., Kaplan, C.D. (2008). The Ibogaine Medical Subculture. Journal of Ethnopharmacology, 115(1), 9-24.
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