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Ibuprofen

No summary available for this substance.

Ibuprofen

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, reduce inflammation, and lower fever. It works by reducing hormones that cause inflammation and pain in the body. It is often used for conditions like headaches, dental pain, menstrual cramps, muscle aches, and arthritis.

Category
Nonsteroidal anti-inflammatory drugs
Molecular Formula
C13H18O2
Mechanism of Action
Ibuprofen inhibits the enzyme cyclooxygenase (COX), preventing the synthesis of prostaglandins, which are mediators of inflammation.
Evidence Grade
A

Other Names

  • Motrin
  • Advil
  • Nurofen
  • Brufen

Primary Benefits

  • Pain relief
  • Reduction of inflammation
  • Lowering fever

Recommended Dosage

Adults 200-400 mg every 4-6 hours as needed
Children 10-15 mg/kg every 6-8 hours as needed

Side Effects

  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Gastric irritation
  • Increased risk of heart attack or stroke

Precautions

  • Avoid use in late pregnancy
  • Caution in patients with heart disease or hypertension
  • Caution in patients with peptic ulcer disease or bleeding disorders

Interactions

  • Aspirin
  • Warfarin
  • Corticosteroids
  • Alcohol
  • Selective serotonin reuptake inhibitors

Key References

  • https://www.ncbi.nlm.nih.gov/books/NBK547742/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855338/
This Food Reversed My Immune Age by 47% in 90 Days
Enhancing Health Through Lifestyle, Diet, and Environmental Choices 36:29 0
“let's talk about prostaglandin E2 which we call an inflammatory molecule so we say oh gee we see a high level of that molecule in the blood if a person has a lot of inflammation so we want to get rid of it how do we get rid of it we block it with an anti-inflammatory drug like uthasin or ibuprofen that blocks PGE2”

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How to Exercise & Eat for Optimal Health & Longevity | Dr. Gabrielle Lyon
Optimizing Health and Longevity Through Nutrition, Exercise, and Supplements 2:31:16 0
“ibuprofen while not inherently bad there's some evidence to suggest that higher doses of ibuprofen can impact muscle Health whether it's hypertrophy or strength.”

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I don’t own or create any of this data—I just organize it and make it searchable, so always double-check with a real doctor before making any health decisions.