Interleukin 6
Interleukin 6 (IL-6) is not a supplement but a naturally occurring protein produced in response to infections and tissue damage. It plays a crucial role in immune response, inflammation, and hematopoiesis. IL-6 is an important mediator of fever and the acute phase response.
- Category
- Cytokine
- Molecular Formula
- C8H8O3
- Mechanism of Action
- Interleukin 6 operates by binding to its receptor, IL-6R. This binding triggers a cascade of events leading to activation of the inflammatory and immune response.
- Evidence Grade
- Not applicable for supplementation
Other Names
- IL-6
- B cell stimulatory factor-2
- BSF-2
- Interferon beta-2
Primary Benefits
- Immune system regulation
- Inflammation response
- Bone health
Recommended Dosage
| Typical Dose |
Not applicable |
| Max Dose |
Not applicable |
Side Effects
- Can cause excessive inflammation if levels are too high
- May contribute to autoimmune disorders
Precautions
- Not typically used as a supplement
- Levels should be regulated in the body
Interactions
- Interactions with other cytokines
- Potential interaction with immunosuppressive medications
Key References
- Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;6(10):a016295. doi:10.1101/cshperspect.a016295
- Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nat Immunol. 2015;16(5):448-457. doi:10.1038/ni.3153
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