isoleucine

No summary available for this substance.

Isoleucine

Isoleucine is one of the nine essential amino acids in humans, important for hemoglobin formation and regulating blood sugar and energy levels. It is a branched-chain amino acid (BCAA) that the body cannot produce on its own, thus it must be ingested, typically through diet or supplements.

Category
Amino Acid
Molecular Formula
C6H13NO2
Mechanism of Action
Isoleucine is used in the biosynthesis of proteins. It also plays a key role in hemoglobin formation and blood sugar and energy level regulation.
Evidence Grade
B

Other Names

  • 2-Amino-3-methylvaleric acid
  • alpha-Amino-beta-methylvaleric acid

Primary Benefits

  • Promotes muscle recovery after exercise
  • Regulates blood sugar levels
  • Boosts energy levels
  • Supports immune function

Recommended Dosage

Adults 19mg per kilogram of body weight per day
Children 28mg per kilogram of body weight per day

Side Effects

  • Nausea
  • Fatigue
  • Headache
  • Dizziness

Precautions

  • People with kidney or liver disease should avoid isoleucine supplements
  • Pregnant or breastfeeding women should consult a healthcare provider before use

Interactions

  • May interact with diabetes medications
  • May affect the absorption of Levodopa

Key References

  • https://www.ncbi.nlm.nih.gov/pubmed/16365087
  • https://www.ncbi.nlm.nih.gov/pubmed/22139564
REVERSE AGING: What To Eat & When To Eat For LONGEVITY | David Sinclair
Enhance Health, Longevity, and Disease Prevention with Lifestyle Choices 1:02:18 0
“just mostly from plant-based sources where there's not a lot of the branched chain amino acids those leucine isoleucine valine amino acids are the ones that activate mtor”

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Protein Amount, Quality and Timing – with Dr. Donald Layman | The Proof Podcast EP 236
Optimal Protein Intake for Health and Muscle Function Explained 1:01:33 0
“all of this is the branch chain amino acid leucine for years since the 1930s we've known that the branch chain amino acids are not metabolized in liver all of the other amino acids are metabolized in liver but these three branch chain leucine, valine and isoleucine get sent out primarily to skeletal muscle so the body has learned to sense it it is senses it as a indicator of protein coming in and basically when that leucine concentration goes up from basically fasting levels to about three times fasting levels uh it triggers a complex inside muscle known as mtor and that's the main sort of Central regulatory function that triggers all these sort of initiation factors and we trigger maximum protein synthesis.”

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What to Eat & When to Eat for Longevity | Lifespan with Dr. David Sinclair #2
Optimal dietary choices and habits for longevity and health benefits 46:00 0
“So, now you've got these amino acids circling in your body, circulating, and there are three ones that are particularly important to know about, it's leucine, ISO leucine and valine also known as the branched-chain amino acids.”

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