Ketamine

No summary available for this substance.

Ketamine

Ketamine is a medication primarily used for induction and maintenance of anesthesia. It induces a trance-like state while providing pain relief, sedation, and memory loss. Other uses include chronic pain and depression management.

Category: Anesthetic
Molecular Formula: C13H16ClNO
Mechanism of Action: Ketamine acts as an antagonist of the NMDA receptor, an ionotropic glutamate receptor in the brain. This action is believed to be responsible for its anesthetic, analgesic, and psychotomimetic effects.
Evidence Grade: A

Other Names

Ketalar
Ketanest
Ketaset

Primary Benefits

Anesthesia induction
Pain relief
Depression management

Recommended Dosage

Adults	1-2 mg/kg IV for anesthesia induction, 0.5 mg/kg for analgesia, 0.5 mg/kg for depression management
Children	1-2 mg/kg IV for anesthesia induction, 0.5-1 mg/kg for analgesia
Elderly	Dose reduction advised due to increased sensitivity

Side Effects

Nausea
Vomiting
Increase in blood pressure
Hallucinations

Precautions

Not recommended for people with severe heart disease
Not to be used in people with a history of psychosis

Interactions

Increased CNS depression with alcohol
Increased hypertension with MAOIs

Key References

'Ketamine: Current applications in anesthesia, pain, and critical care.' Anesth Essays Res. 2014
'Ketamine for Treatment-Resistant Depression.' Neuropsychopharmacology. 2015

Breaking Bad Habits & Living Your Best Life – Dr Andrew Huberman (4K)

Optimizing Health and Functionality Through Sleep and Rhythm Management 1:01:01 ⁰

“the use of drugs like ketamine you know FDA approved drug for dissociating your emotions while in the presence of MDMA right or MDMA which just recently uh day before yesterday did failed to pass approval by the FDA for the treatment of PTSD”

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