Ketone Ester

Ketone Ester

Ketone esters are a type of exogenous ketone supplement that can be ingested to increase blood ketone levels. They are synthetically made by combining an alcohol to a ketone body. They are often used by athletes for energy, and by individuals following a ketogenic diet to maintain a state of ketosis.

Category

Dietary supplement

Molecular Formula

Variable, depends on the specific ester

Mechanism of Action

Ketone esters are broken down in the liver to produce ketones, which are then used as a source of energy. This mimics the natural process of ketosis, where the body uses fat for energy when carbohydrate stores are low.

Evidence Grade

C

Other Names

• Exogenous ketones
• Ketone bodies

Primary Benefits

• Increased energy
• Enhanced athletic performance
• Weight loss
• Cognitive enhancement

Recommended Dosage

Side Effects

• Nausea
• Stomach discomfort
• Bad breath

Precautions

• Not recommended for individuals with type 1 diabetes
• Can cause hypoglycemia if taken with insulin
• Should not be used as a replacement for a balanced diet

Interactions

• Can interact with diabetes medication

Key References

• Stubbs, B. J., Cox, P. J., & Evans, R. D. (2017). A Ketone Ester Drink Lowers Human Ghrelin and Appetite. Obesity, 25(2), 297-305.