Lipoic acid

No summary available for this substance.

Lipoic acid

Lipoic acid, also known as alpha-lipoic acid (ALA), is an organic compound that acts as a potent antioxidant in the body. It's synthesized in small amounts by humans but can also be obtained from certain foods or supplements. It plays a crucial role in energy metabolism and has been used to help improve a variety of health conditions.

Category
Antioxidant
Molecular Formula
C8H14O2S2
Mechanism of Action
Lipoic acid serves as a coenzyme in the mitochondria's energy-producing metabolic cycles. It also exhibits strong antioxidant properties by neutralizing harmful free radicals, regenerating other antioxidants, and chelating heavy metals.
Evidence Grade
B

Other Names

  • Alpha-lipoic acid
  • ALA
  • Thioctic acid

Primary Benefits

  • Enhanced antioxidant protection
  • Improved insulin sensitivity
  • Reduced inflammation
  • Neuroprotective effects

Recommended Dosage

Low Dose 200mg per day
Average Dose 300-600mg per day
High Dose Up to 1800mg per day

Side Effects

  • Nausea
  • Rash
  • Stomach upset

Precautions

  • People with diabetes should monitor their blood sugar levels
  • Pregnant or breastfeeding women should consult their doctor

Interactions

  • May lower blood sugar levels, affecting diabetes medications
  • May impact chemotherapy effectiveness

Key References

  • Packer, L., Witt, E.H., & Tritschler, H.J. (1995). Alpha-Lipoic Acid as a Biological Antioxidant. Free Radical Biology and Medicine, 19(2), 227-250.
How to Optimize Female Hormone Health for Vitality & Longevity | Dr. Sara Gottfried
Optimizing Women's Health: Hormones, Nutrition, Exercise, and Genetics Insights 37:44 0
“What I like to do with nutritional testing is run a panel that's looking at antioxidants like vitamin A, vitamin C, Alpha lipoic acid, plant-based antioxidants. You can measure that in the blood.”

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The Shady Reality of the $Billion Supplement Industry | The Dr. Hyman Show
Understanding Supplement Quality, Nutrition Myths, and Modern Health Realities 1:04:16 0
“An acetylcysteine is a compound that boosts glutathione. There's also other things like lipoic acid and you wouldn't know this.”

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The 5 Compounds that Detoxify & Protect the Brain (neuroprotectants) – Dr. Sherr
Understanding the Visual Programming Language Processing for Creative Expression 0:00 0
“what alphalapoic acid can do is that it helps in that mitochondria it helps neutralize free radicals directly and then at the same time it recycles your major antioxidants your glutathione your vitamin C your vitamin E”

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The 5 Compounds that Detoxify & Protect the Brain (neuroprotectants) – Dr. Sherr
Understanding the Visual Programming Language Processing for Creative Expression 0:13 0
“it also upregulates another pathway called the NRF2 pathway the NRF2 pathway is the pathway that helps you produce more glutathione in your brain as well”

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The 5 Compounds that Detoxify & Protect the Brain (neuroprotectants) – Dr. Sherr
Understanding the Visual Programming Language Processing for Creative Expression 3:55 0
“alphalopoic acid is one of the unsung antioxidants out there people have heard of glutathione and vitamin C and vitamin E alphalapoic acid is actually the one that recycles all of those to make them more effective in the body”

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The 5 Compounds that Detoxify & Protect the Brain (neuroprotectants) – Dr. Sherr
Understanding the Visual Programming Language Processing for Creative Expression 5:15 0
“alphalapoic acid can do is that it helps in that mitochondria it helps neutralize free radicals directly and then at the same time it recycles your major antioxidants your glutathione your vitamin C your vitamin E it also upregulates another pathway called the NRF2 pathway”

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The 5 Compounds that Detoxify & Protect the Brain (neuroprotectants) – Dr. Sherr
Understanding the Visual Programming Language Processing for Creative Expression 6:34 0
“alphamoic acid is one of the best toxin neutralizers out there it actually can bind and neutralize cadmium mercury arsenic and lead”

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The 5 Compounds that Detoxify & Protect the Brain (neuroprotectants) – Dr. Sherr
Understanding the Visual Programming Language Processing for Creative Expression 7:27 0
“it also increases insulin sensitivity and so more you know you're going to have more glucose that goes into the cell as opposed to if you're more insulin resistance”

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The 5 Compounds that Detoxify & Protect the Brain (neuroprotectants) – Dr. Sherr
Understanding the Visual Programming Language Processing for Creative Expression 10:33 0
“some people will be more sensitive to sulfur containing uh things like glutathione or like alphapoic acid and they may get more sulfur-l like symptoms of sometimes in people can cause some oxidative stress itself”

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The 5 Compounds that Detoxify & Protect the Brain (neuroprotectants) – Dr. Sherr
Understanding the Visual Programming Language Processing for Creative Expression 11:44 0
“alpha lipopic acid we're mostly deficient in it most of us could use it on a regular basis um be careful with it before exercise maybe after for recovery especially if you want that hormetic stress of it”

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These FOODS & HABITS Boost Brain Health & REDUCE INFLAMMATION | Mark Hyman
Boost Brain Health with Anti-Inflammatory Foods and Healthy Habits 51:09 0
“there's a whole cocktail of mitochondrial supplements lipoic acid b vitamins niacin riboflavin that are so critical to making energy”

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