Magnesium threonate

Magnesium threonate

Magnesium threonate is a nutritional supplement compound developed to enhance the bioavailability of magnesium in the brain. It is a unique form of magnesium that is delivered into the brain where it maintains the quantity of synaptic connections between brain cells and supports important cellular functions, making it an interesting subject of research in neurodegenerative diseases.

Category

Minerals

Molecular Formula

C8H14MgO10

Mechanism of Action

Magnesium threonate works by increasing the levels of magnesium in the brain, as it is able to cross the blood-brain barrier more effectively than other forms of magnesium. This enhances synaptic density and plasticity, which are critical for learning and memory.

Evidence Grade

B - Moderate evidence for health-related claims

Other Names

• L-Threonic acid Magnesium salt
• MgT
• Neuro-Mag

Primary Benefits

• Enhances cognitive function
• Supports memory and learning
• Helps regulate sleep quality
• May help manage symptoms of depression and anxiety

Recommended Dosage

Side Effects

• Headache
• Drowsiness
• Diarrhea
• Nausea

Precautions

• Not recommended for those with kidney disease
• Consult a healthcare provider before use if pregnant or breastfeeding

Interactions

• May interact with calcium channel blockers
• May interact with diuretics
• May decrease absorption of certain antibiotics if taken simultaneously

Key References

• Slutsky, I., et al. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron, 65(2), 165-177.
• Liu, G., et al. (2015). Efficacy and safety of MMFS-01, a synapse density enhancer, for treating cognitive impairment in older adults: a randomized, double-blind, placebo-controlled trial. Journal of Alzheimer's Disease, 49(4), 971-990.