Methyl B12
Methyl B12, also known as Methylcobalamin, is a form of vitamin B12 that is considered to be more bioavailable and neurologically active. It plays a crucial role in the normal functioning of the brain, nervous system, and for the formation of blood. It is also involved in the cellular metabolism of carbohydrates, proteins, and lipids to produce energy.
- Category
- Vitamin
- Molecular Formula
- C63H91CoN13O14P
- Mechanism of Action
- Methyl B12 acts as a coenzyme for methionine synthase, which catalyzes the conversion of homocysteine to methionine, an essential amino acid. It also contributes to the synthesis of S-adenosylmethionine (SAMe), a universal methyl donor for almost 100 different substrates, including DNA, RNA, hormones, proteins, and lipids.
- Evidence Grade
- B
Other Names
- Methylcobalamin
- Mecobalamin
- Metacobalamin
- Methylcobalamin B12
Primary Benefits
- Supports nerve tissue health
- Promotes optimal sleep
- Boosts mood and energy levels
- Supports heart health
Recommended Dosage
| Adults |
2.4 mcg per day |
| Pregnant Women |
2.6 mcg per day |
| Breastfeeding Women |
2.8 mcg per day |
Side Effects
- Headache
- Itching
- Swelling
- Nervousness
- Anxiety
- Involuntary or uncontrollable movements
Precautions
- People with allergies or sensitivity to cobalt or cobalamin should avoid Methyl B12
- People with Leber's disease should not take Methyl B12
- Should be used cautiously in individuals with kidney problems or receiving kidney dialysis
Interactions
- Chloramphenicol
- Colchicine
- Proton pump inhibitors
- H2 receptor antagonists
- Metformin
Key References
- Lewerin C, Jacobsson S, Lindstedt G, Nilsson-Ehle H. Serum biomarkers for atrophic gastritis and antibodies against Helicobacter pylori in the elderly: implications for vitamin B12, folic acid and iron status and response to oral vitamin therapy. Scand J Gastroenterol. 2008;43(2):105-111.
- Suzuki K, Watanabe T, Sakamoto S, et al. Randomized, Double-Blind, Placebo-Controlled Trial of Vitamin B12 Supplement to Improve Cognitive Function in Older Adults with Mild Cognitive Impairment. J Gerontol A Biol Sci Med Sci. 2020;75(10):1988-1993.
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