Methyl folate

No summary available for this substance.

Methyl folate

Methyl folate, also known as L-methylfolate, is the biologically active form of vitamin B9. It plays a critical role in methylation, a process that happens in every cell of the body and helps with DNA synthesis and repair, neurotransmitter production, and immune function.

Category: Vitamin
Molecular Formula: C20H23N7O6
Mechanism of Action: Methyl folate is used directly by the body for methylation, bypassing the need for conversion which is required for folic acid. It helps in the conversion of homocysteine to methionine, an essential amino acid, and aids in the production of S-adenosylmethionine (SAMe), a compound involved in immune function and mood.
Evidence Grade: A

Other Names

L-methylfolate
5-MTHF
Levomefolic acid

Primary Benefits

Supports DNA synthesis and repair
Helps with neurotransmitter production
Boosts immune function
May improve mood and reduce symptoms of depression

Recommended Dosage

Adults	400 to 800 micrograms per day
Children	Depends on age, generally 150-400 micrograms per day

Side Effects

Nausea
Bloating
Loss of appetite

Precautions

People with a history of cancer should consult a doctor before use
Pregnant or breastfeeding women should consult a healthcare provider before use

Interactions

Antacids and proton pump inhibitors can decrease absorption
Can interfere with the anti-seizure medication phenytoin

Key References

https://www.ncbi.nlm.nih.gov/pubmed/24494987
https://www.ncbi.nlm.nih.gov/pubmed/20608755

Gary Brecka: The TRUTH About Biohacking, Light Therapy, and Nutrients

Optimizing Health: Lifestyle, Nutrition, Sleep, Exercise, and Social Connections 1:20:11 ⁰

“if your level of homosysteine which is a a blood test that is better than just checking your folate in your blood is if your fet's over 14 you you increase your risk of Dementia by 50% so this is just simp things you can do to actually so true and if you have if you have hyper homosymia you know we we've um and I'm I'm I'm preparing to publish this data so we have about 150,000 patients that have that we've done um blood work on 70 7 uh4 biomarkers and then also done a methylated genetic test looking at the main markers of methylation compt mtrr MTR ahcy and and mtfr um contrary to popular belief if you have MTHFR you need to to avoid folic acid like the plague and you have to supplement with methyl folate five methyl folate um and the the the the proof in what's called s-phase arrest which is essentially when the DNA is replicating um and and copying itself or even when it's making a transcription an mRNA message um something called s-phase arrest which is designed to stop the passing of genetic mutations um when when the cell goes…”

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Dr. Nayan Patel: Unlocking Glutathione Your Body’s Super Antioxidant | TUH #057

Exploring the Vital Role of Glutathione in Health and Wellness 27:41 ⁰

“why can't you take folic acid because folic acid has to convert to methyl folate to get absorbed in your body”

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Exploring the Vital Role of Glutathione in Health and Wellness 28:28 ⁰

“when they would switch to methyl folate simple switch to the methylated form of that nutrient Boom the anemia would go away right away”

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Dr. Peter Attia: Supplements for Longevity & Their Efficacy

Supplements, Lifestyle, and Strategies for Longevity and Optimal Health 2:15:57 ⁰

“we know that if you take methyl folate and uh uh methyl B12 you're going to lower homocysteine that's abundantly clear so the the thinking is that that might actually lower um adma sdma and raise nitri oxide synthes again relatively low cost lowrisk you know thing to take at modest doses”

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