Methylene blue

No summary available for this substance.

Methylene Blue

Methylene Blue is a synthetic compound of dark green crystals or crystalline powder, having a bronze-like luster. It is used in medicine, mainly to treat methemoglobinemia. It also has potential effects on mitochondria and the nervous system, and has been studied as an enhancer for memory and mental function.

Category
Pharmaceutical
Molecular Formula
C16H18ClN3S
Mechanism of Action
Methylene blue acts as a redox agent. It donates high-energy electrons to recycle the enzyme responsible for converting methemoglobin back to hemoglobin. Also, it enhances mitochondrial complex IV activity.
Evidence Grade
B

Other Names

  • Methylthioninium chloride
  • Urolene Blue
  • Tetramethylthionine

Primary Benefits

  • Treats methemoglobinemia
  • Potential cognitive enhancement
  • Antimicrobial effects
  • Neuroprotective effects

Recommended Dosage

Standard 1-2 mg/kg body weight
Maximum Not to exceed 7 mg/kg body weight

Side Effects

  • Nausea
  • Stomach upset
  • Diarrhea
  • Vomiting
  • Headache
  • Dizziness

Precautions

  • Allergic reactions
  • Avoid in patients with severe renal dysfunction
  • Use with caution in pregnancy and lactation

Interactions

  • Antidepressants
  • Monoamine oxidase inhibitors (MAOIs)
  • Dietary supplements containing tyramine

Key References

  • Peter, C., Hongwan, D., Küpfer, A., & Lauterburg, B. H. (2000). Pharmacokinetics and organ distribution of intravenous and oral methylene blue.
  • Schirmer, R. H., Adler, H., Pickhardt, M., & Mandelkow, E. (2011). Lest we forget you—methylene blue...
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver
Exploring Peptides, Hormones, and Therapies for Health and Wellness 1:45:43 0
“Methylene blue when we talk about the mitochondria using that mitochondrial membrane binds to cytochrome C oxidase and I think of it you know traditionally it's used when people have carbon Bon oxide poisoning they'll still use it you go in emergency your carbon monoxide poison it'll give you methylene blue and it helps your red blood cells displace the the carbon monoxide and put oxygen there and so you're it's an oxygenator.”

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Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver
Exploring Peptides, Hormones, and Therapies for Health and Wellness 1:47:36 0
“it's 10 milligrams of methylene blue combined and you've got some other things in the cocktail version that you make take it in the morning on an empty stomach yeah I you could take it with food though again it's going to be well absorbed um it will interesting to people and I need to say it will turn your urine green or blue for how long um about 24 hours hour depending and that be kind of fun yeah well and a good caveat is if it doesn't and I've had patients then that's interesting to me as a clinician because it means that your mitochondria is not working well right like the way I see this is you should get spill over you shouldn't kind of use it all and if you're not there's something wrong there that you're using all of it and you're getting no spill over back into your bloodstream which gets filtered into your bladder your urine which you urinate out that and that's happened with a couple patients so it's like oh wow you had no green or blue urine there's a problem with your mitochondria.”

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Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver
Exploring Peptides, Hormones, and Therapies for Health and Wellness 1:48:39 0
“there's the you know a mild MAOI inhibitor which is monamine oxidase inhibitor yeah which going to allow things like serotonin to work a little bit longer in that synaptic Clift um you know and you've expounded way better than I can about serotonin and dop me and how those work but um there is a cognitive enhancement from it for sure it's very real and we have a lot of people using it and love it it also seems to be an antiviral you know you get this again that's probably through the mitochondria making your mitochondria more efficient it's a prescription drug it's a prescription drug but there's there's now and I don't totally understand it there's now strictly over-the-counter neutral supplement options that are methylene blue for sure anyone can go online and buy it for sure trust me now now there there are going to be a few and and you talked about turning your mouth blue if you take a liquid form right uh and we'll do that sometimes in the office when we're doing other treatments we'll give a big dose of methylene blue to kind of help fuel kind of quickly make a…”

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#148 – Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the ITP
Understanding Longevity: Research, Substances, Genetics, Diet, and Implications 1:26:24 0
“Methylene blue, curcumin, many of these other things that have been tested.”

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The Simple Blueprint to Reverse Disease
Optimizing Health Through Natural Lifestyle and Nutritional Adjustments 1:17:24 0
“I'm not a fan of methylene blue I want people to understand this is not a healthy thing for humans.”

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The Simple Blueprint to Reverse Disease
Optimizing Health Through Natural Lifestyle and Nutritional Adjustments 1:18:40 0
“methylene blue not for healthy humans only to be used in very specific context it's a Band-Aid it doesn't fix anything it doesn't make you healthier”

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Dr. David Sinclair: The Biology of Slowing & Reversing Aging
Strategies to Slow Aging and Optimize Health for Longevity 1:52:36 0
“There are people out there who are ingesting methylene blue. And when I was a kid, I used methylene blue to clean my fish tank.”

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