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MPA

No summary available for this substance.

MPA

MPA, or Medroxyprogesterone acetate, is a synthetic derivative of progesterone, a naturally occurring steroid hormone. It is mainly used as a contraceptive in the form of depot medroxyprogesterone acetate (DMPA) and as part of menopausal hormone therapy for the treatment of menopausal symptoms.

Category
Hormone
Molecular Formula
C24H34O4
Mechanism of Action
MPA works by binding to and activating the progesterone receptor, thus inhibiting the secretion of gonadotropins, which in turn prevents follicular maturation and ovulation.
Evidence Grade
A

Other Names

  • Depo-Provera
  • Provera
  • Depo-SubQ Provera 104

Primary Benefits

  • Contraception
  • Menopausal symptom relief
  • Endometriosis management

Recommended Dosage

Daily 5-10mg orally for 5-10 days
Monthly 150mg intramuscularly every 3 months

Side Effects

  • Weight gain
  • Depression
  • Nausea
  • Insomnia
  • Breast tenderness

Precautions

  • Not recommended for individuals with a history of breast cancer or stroke
  • Avoid use in liver disease
  • Not recommended for individuals with a history of depression

Interactions

  • Aminoglutethimide
  • Rifampin
  • St. John's Wort

Key References

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640232/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278585/
Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
Proactive Health Strategies: Preventing Chronic Conditions Through Lifestyle Choices 2:45:49 0
“these women were on average considerably older they were I want to say 7 to 10 years out of menopause at this point um and the study was looking at a number of outcomes but it was terminated early at about 5 and 1/2 years when it was noted that the women in the CE plus MPA group versus the placebo had um a 0.1% higher risk of developing breast cancer”

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Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity
Optimizing Health and Longevity Through Nutrition, Hormones, and Exercise 1:18:00 0
“So the relative risk increase of breast cancer in the estrogen plus MPA group versus the placebo was 25, 27%.”

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I don’t own or create any of this data—I just organize it and make it searchable, so always double-check with a real doctor before making any health decisions.