NN

No summary available for this substance.

Nicotinamide Riboside (NR)

Nicotinamide Riboside (NR) is a form of vitamin B3 that's used as a supplement for anti-aging and cognitive health benefits. It plays a role in energy production and supports cellular health by contributing to the creation of NAD+, a coenzyme involved in several metabolic processes.

Category
Vitamin B3 derivative
Molecular Formula
C11H15N2O5P
Mechanism of Action
Nicotinamide Riboside (NR) is converted into Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme that plays a crucial role in metabolic processes, DNA repair, and cell aging.
Evidence Grade
C

Other Names

  • Niagen
  • NR

Primary Benefits

  • Supports cellular health
  • Promotes energy metabolism
  • May have neuroprotective effects
  • Potentially slows the aging process

Recommended Dosage

Adults 100-300 mg per day

Side Effects

  • Nausea
  • Fatigue
  • Headache
  • Indigestion

Precautions

  • Pregnant or breastfeeding women should consult their doctor before use
  • People with a history of ulcers or gout should use with caution

Interactions

  • Alcohol: May increase the risk of liver damage
  • Antibiotics: Some antibiotics could interfere with the way vitamin B3 works in your body

Key References

  • Chi, Y., & Sauve, A. A. (2013). Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Current Opinion in Clinical Nutrition & Metabolic Care, 16(6), 657–661.
  • Trammell, S. A., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., ... & Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature communications, 7(1), 1-14.
Breaking Bad Habits & Living Your Best Life – Dr Andrew Huberman (4K)
Optimizing Health and Functionality Through Sleep and Rhythm Management 2:24:13 0
“when I take sublingual NN my hair grows faster, my nails grow thicker and faster... and I have more morning energy.”

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Breaking Bad Habits & Living Your Best Life – Dr Andrew Huberman (4K)
Optimizing Health and Functionality Through Sleep and Rhythm Management 2:24:31 0
“I don't take it because it's very expensive relative to NN and even though I probably could afford it I didn't subjectively feel much.”

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Dr. Peter Attia: Supplements for Longevity & Their Efficacy
Supplements, Lifestyle, and Strategies for Longevity and Optimal Health 1:33:34 0
“NR can cross the cell membrane directly NN cannot okay but you can just CLE the phosphate group right exactly um NR they claim I'm not this is not my claim but they claim that NR is quote unquote 25% more effective than NN in raising whole blood NAD levels but I'm guessing that's milligram for milligram right okay so then you just adjust the milligram dosage a little bit and so on”

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