phosphatidylserine

No summary available for this substance.

Phosphatidylserine

Phosphatidylserine is a phospholipid, which is a type of fat that's integral to the structure and functioning of cell membranes throughout the body. It's particularly abundant in the brain, where it plays a key role in cellular function and communication. It's also involved in maintaining the health and integrity of nerve cells and supports memory and cognitive function.

Category
Nutritional Supplement
Molecular Formula
C13H24NO10P
Mechanism of Action
Phosphatidylserine works by supporting the health and function of cell membranes, particularly in the brain. This helps maintain the fluidity and permeability of cells, facilitating communication between them and promoting healthy cognitive function.
Evidence Grade
B - Moderate evidence for health benefits

Other Names

  • PS
  • Phosphatidylserine Complex

Primary Benefits

  • Supports cognitive function
  • Promotes memory and learning
  • Helps maintain cell health

Recommended Dosage

Standard 100 mg taken three times daily
Maximum 300 mg per day

Side Effects

  • Insomnia
  • Stomach upset
  • Headache

Precautions

  • Not recommended for those on anticoagulant or antiplatelet medications
  • Pregnant and breastfeeding women should consult their doctor

Interactions

  • May interact with anticoagulant and antiplatelet drugs

Key References

  • Kim HY, Huang BX, Spector AA. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res. 2014;56:1-18.
  • Blokland A, Honig W, Brouns F, Jolles J. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS. Nutrition. 1999;15(10):778-783.
How to Optimize Female Hormone Health for Vitality & Longevity | Dr. Sara Gottfried
Optimizing Women's Health: Hormones, Nutrition, Exercise, and Genetics Insights 1:38:54 0
“phosphatidylserine PS for short fish oil also more modestly reduces cortisol”

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How to Optimize Female Hormone Health for Vitality & Longevity | Dr. Sara Gottfried
Optimizing Women's Health: Hormones, Nutrition, Exercise, and Genetics Insights 1:42:29 0
“I need a phosph Serene in the morning for people who are high at night who have what's known as a flat cortisol pattern or a inverted pattern you want to take it at night.”

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276 ‒ Special episode: Peter on longevity, supplements, protein, fasting, apoB, statins, & more
Longevity, Health Tools, Proactive Management: Nutrition, Exercise, Supplements, Genetic Insights 35:08 0
“Occasionally for travel I will take Gyros phosphatidylserine... I'll usually take about 400 milligrams.”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 7:38 0
“Thesis understands this, and, as far as I know, they're the first nootropics company to create targeted nootropics for specific outcomes.”

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