Polyphenols

No summary available for this substance.

Polyphenols

Polyphenols are a category of chemicals that naturally occur in plants. There are more than 500 unique polyphenols. Foods such as fruits, vegetables, tea, and wine contain polyphenols. They possess antioxidant properties and contribute to overall health.

Category
Bioactive compounds
Molecular Formula
C6H5OH
Mechanism of Action
Polyphenols work primarily as antioxidants, helping to neutralize harmful free radicals in the body. They also exhibit anti-inflammatory, antiviral, and anticancer properties.
Evidence Grade
B

Other Names

  • Phenolics
  • Phytochemicals

Primary Benefits

  • Antioxidant effects
  • Anti-inflammatory effects
  • Potential anticancer properties
  • Heart health support

Recommended Dosage

Daily Intake 1000-1500 mg
Unit mg
Notes The dosage recommendation varies based on the source of polyphenols and individual health conditions.

Side Effects

  • Stomach upset
  • Diarrhea
  • Nausea

Precautions

  • People with allergies to certain plants should exercise caution.
  • Not recommended for pregnant or breastfeeding women without medical advice.

Interactions

  • May interact with blood thinners
  • May affect the absorption of iron and other minerals

Key References

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429336/
Axel Montagne, PhD, on Solving Alzheimer’s and Dementia with Blood-Brain Barrier Repair
Polyphenols 1:28:16 0
“red wine are full of polyphenols that you know from The Grapes which has been shown to be very important for brain functions and also for vascular functions”

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How to Optimize Female Hormone Health for Vitality & Longevity | Dr. Sara Gottfried
Optimizing Women's Health: Hormones, Nutrition, Exercise, and Genetics Insights 26:29 0
“intake of vegetables polyphenols is such an important predictor of future risk of breast cancer like when you're 50 60 plus and the most important time is when you're a teenager”

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Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver
Exploring Peptides, Hormones, and Therapies for Health and Wellness 1:33:08 0
“very few things in nature induce phase two independent of phase one meaning most of us have trash piled up on the side of our road those things are the polyphenols right and so things like the blues the Reds the pigments that's why it's important to eat a wide variety of colors in your diet matcha tea you know has a very strong inducing effect on Phase 2 liver activity”

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NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Lifespan with Dr. David Sinclair #4
Exploring Longevity Molecules and Health Benefits for Lifespan Extension 43:00 0
“red wine has more than resveratrol and it has some of these other xenohermetic polyphenols that we talked about in earlier episodes that could give a combination effect.”

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The Root Cause of Metabolic Dysfunction w/ Dr. Casey Means
Understanding Metabolic Health: Risks, Dysfunction, and Dietary Recommendations 1:08:17 0
“the microbiome eats polyphenols and fiber and then it's going to have a pro effect through the short chain fatty acids they create”

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The Root Cause of Metabolic Dysfunction w/ Dr. Casey Means
Understanding Metabolic Health: Risks, Dysfunction, and Dietary Recommendations 1:08:32 0
“a tablespoon of refined sugar that has no polyphenols, no antioxidants, no micronutrients, no vitamins and minerals, no fiber, nothing; it's just a straight up it's a drug that's what it is”

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Why Paul Saladino, MD Quit A 100% Carnivore Diet, Impacts of Cholesterol, And the Value of Insulin
Rethinking Nutrition: Meat, Deception, Health Shifts, and Dietary Innovations 22:45 0
“there's polyphenols and and prebiotics and you look at a a piece of fruit it's probably over 5,000 components in that piece of fruit”

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The Intermittent FASTING MISTAKES That Make You GAIN WEIGHT! | Dave Asprey
Optimizing Health Through Fasting: Strategies, Benefits, and Considerations 3:05 0
“you don't have to do that to get the benefits in fact you'll probably get more if you have some polyphenols during your fast”

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The Intermittent FASTING MISTAKES That Make You GAIN WEIGHT! | Dave Asprey
Optimizing Health Through Fasting: Strategies, Benefits, and Considerations 12:11 0
“fasting can help you lose weight but if you have good gut bacteria present and you're aware of that fact you can do things like consume that tea those polyphenols that feeds good bacteria called the bacteriodes family so the colored compounds and fruits and vegetables and coffee and tea and chocolate are all prebiotics for good gut bacteria that you cannot buy in a probiotic and so having healthy gut bacteria resolves that problem”

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Longevity Doctor: I’m 79 With the Health of a 40 Year Old, Here’s How I Did It!
Maximizing Health Potential Through Genetics, Nutrition, and Lifestyle Choices 53:43 0
“Here is where the polyphenols play a principle role. This may be, as you said earlier, this list of nutrients that have only gotten a page or two publication in nutrition textbooks because weren't considered to be essential nutrients.”

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This Food Reversed My Immune Age by 47% in 90 Days
Enhancing Health Through Lifestyle, Diet, and Environmental Choices 42:34 0
“foods in Sardinia but they have this very high polyphenol content they are very colored with their different phyitochemicals things that we have never taken seriously in American nutrition.”

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This Food Reversed My Immune Age by 47% in 90 Days
Enhancing Health Through Lifestyle, Diet, and Environmental Choices 58:52 0
“it has effects on um the microbiome in ways 58:52 that help blood sugar control so there's so much going on there not just the fiber in it but also the polyphenols 58:58 which now are needed for gut microbiome health”

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REVERSE AGING: What To Eat & When To Eat For LONGEVITY | David Sinclair
Enhance Health, Longevity, and Disease Prevention with Lifestyle Choices 50:06 0
“resveratrol and some other plant polyphenols are highly insoluble once you pull them out of the plant and process them”

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REVERSE AGING: What To Eat & When To Eat For LONGEVITY | David Sinclair
Enhance Health, Longevity, and Disease Prevention with Lifestyle Choices 50:37 0
“we discovered all of these extended lifespan back in the 2000s we first showed it in yeast and then worms”

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Let Food Be Thy Medicine: EAT THIS To Heal The Body & STARVE CANCER! | Dr. William Li
Food as medicine to prevent disease and promote health naturally 40:09 0
“Spanish olive oil I look for Picual, among the highest in polyphenols in the oil so the olive oil will be loaded.”

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Let Food Be Thy Medicine: EAT THIS To Heal The Body & STARVE CANCER! | Dr. William Li
Food as medicine to prevent disease and promote health naturally 40:18 0
“Greek olive oil, the Koroneiki olive, which is from the Peloponnesis, both the Picual and Koroneiki are very common olives so that's good news, it's not very expensive, highest amount of polyphenols.”

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Let Food Be Thy Medicine: EAT THIS To Heal The Body & STARVE CANCER! | Dr. William Li
Food as medicine to prevent disease and promote health naturally 51:30 0
“cow dairy okay actually is fat milk has got fat in it like butter which is made out of milk and um and the fat when you put it into your tea does change its flavor but that's not what we're talking about here we're talking about the fact that when milk or cream is put into tea the fat molecules in the cow dairy form little soap bubbles these are microscopic soap bubbles they're called micelles fat likes to stick with fat and so tea is mostly water and so when you pour milk into tea the the bubbles the dairy fat sticks together and a little makes a little tiny soap bubble and what does it do those sub bubbles trap the polyphenols from tea it traps the catechin so you've got some good stuff wrapped in a soap bubble of of dairy and now when you drink the tea the catechin is trapped in the soap bubble it doesn't get absorbed as easily in your stomach and it just rolls down your gut and a lot of it comes out the other end okay and so you're missing out on a lot of the good stuff you…”

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Let Food Be Thy Medicine: EAT THIS To Heal The Body & STARVE CANCER! | Dr. William Li
Food as medicine to prevent disease and promote health naturally 53:00 0
“nut milks are fine because they don't actually have the same fatty reaction that the dairy cow dairy has so almond milk uh cashew milk um those those soy milk they're all fine”

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The Nutritional Scientist: Do Not Eat After 9pm! Link Between Chewing & Belly Fat!
Proper Eating Habits for Weight Loss and Healthy Digestion Tips 5:16 0
“food contains nutrients that people are very familiar with like protein, fat, fiber, carbohydrate... food also contains thousands of other chemicals many of these we call bioactives that you have heard of like polyphenols, vitamins, minerals, etc.”

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The Nutritional Scientist: Do Not Eat After 9pm! Link Between Chewing & Belly Fat!
Proper Eating Habits for Weight Loss and Healthy Digestion Tips 8:18 0
“processing gone bad is when you've change the nutrient profile of a food such that it is unhealthy so in simple terms it's too much saturated fat, too much salt, too little fiber, too little bioactives like polyphenols.”

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The Chronic Disease Expert: We Can Now Reverse Stage 4 Cancer! This Is Feeding Your Cancer Cells!
Revolutionize Health Through Nutrition: Overcoming Chronic Diseases and Cancer 1:40:57 0
“Coffee beans contain many polyphenols including chlorogenic acid. Chlorogenic acid is anti-inflammatory. Chlorogenic acid also turns on your brown fat.”

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The Chronic Disease Expert: We Can Now Reverse Stage 4 Cancer! This Is Feeding Your Cancer Cells!
Revolutionize Health Through Nutrition: Overcoming Chronic Diseases and Cancer 1:57:10 0
“I would bring coffee. Okay. Um because of all the polyphenols in coffee, I'd bring tea.”

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These FOODS & HABITS Boost Brain Health & REDUCE INFLAMMATION | Mark Hyman
Boost Brain Health with Anti-Inflammatory Foods and Healthy Habits 48:25 0
“omega-3 fats other good fats and polyphenols um and there's a whole category of other things that can be helpful so in terms of the omega-3 fats the fatty fish is really important we talked about things like olive oil avocados nuts and seeds great for the brain”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 13:02 0
“So food scarcity was something common as well as eating plants, so getting these compounds that I mentioned. These are all types of stress, intermittent challenges, that activate genetic pathways in our bodies.”

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The Most Important Daily Habits For Health & Longevity – Dr Rhonda Patrick (4K)
Essential Omega-3 for Health, Longevity, and Disease Prevention Strategies 2:56:28 0
“it's a bunch of protocols that that have been uh evidence-based that are you know how to increase bdnf exercise protocols sauna protocols polyphenols”

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