Psilocybin mushrooms
Psilocybin mushrooms, also known as 'magic mushrooms', are a group of fungi that contain the psychoactive compounds psilocybin and psilocin. These substances are known for their hallucinogenic effects, and have been used traditionally in many cultures for spiritual and healing purposes. Recent scientific research has begun to explore their potential benefits for mental health conditions such as depression and anxiety.
- Category
- Psychoactive substances
- Molecular Formula
- C12H17N2O4P
- Mechanism of Action
- Psilocybin is a prodrug that is converted into psilocin in the body, which is believed to act primarily by binding to serotonin receptors in the brain, particularly the 5-HT2A receptor.
- Evidence Grade
- C
Other Names
- Magic mushrooms
- Shrooms
- Psychedelic mushrooms
Primary Benefits
- May help relieve symptoms of depression
- May reduce anxiety
- Potential to aid in addiction treatment
Recommended Dosage
| Microdosing |
0.1-0.3g dried mushrooms |
| Moderate Dose |
1-2.5g dried mushrooms |
| High Dose |
5g dried mushrooms |
Side Effects
- Hallucinations
- Nausea
- Increased heart rate
- Panic attacks
- Bad trips
Precautions
- Not to be used by individuals with a history of psychosis
- Avoid if pregnant or breastfeeding
- Avoid combining with other psychoactive substances
Interactions
- May interact negatively with SSRIs
- May interact negatively with other psychoactive drugs
Key References
- Griffiths, R.R., et al. (2006). 'Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance.' Psychopharmacology, 187(3), 268-283.
- Carhart-Harris, R.L., et al. (2017). 'Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.' Psychopharmacology, 235(2), 399-408.
No comments yet.