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Pterostilbene

No summary available for this substance.

Pterostilbene

Pterostilbene is a naturally occurring dietary compound, primarily found in blueberries and grapes. It is similar in structure to the anti-aging compound resveratrol, but is more bioavailable and has shown potential for improved benefits. It is known for its antioxidant, anti-inflammatory, and anticarcinogenic properties.

Category
Nutritional Supplement
Molecular Formula
C16H16O3
Mechanism of Action
Acts as a powerful antioxidant and anti-inflammatory agent, potentially impacting various pathways to delay aging and fight diseases. It also activates the peroxisome proliferator-activated receptor (PPAR) and sirtuin 1 (SIRT1), promoting overall health.
Evidence Grade
C

Other Names

  • 3',5'-Dihydroxy-4'-methoxy-trans-stilbene
  • Desmethoxyresveratrol
  • Dimethoxyresveratrol

Primary Benefits

  • Antioxidant benefits
  • Anti-inflammatory effects
  • Potential anticancer properties
  • Improvement in cognitive function
  • Supports cardiovascular health

Recommended Dosage

Adults 50-250 mg per day
Children Not recommended for children

Side Effects

  • Nausea
  • Headache
  • Dizziness

Precautions

  • Pregnancy and breastfeeding
  • Surgery: Stop using at least 2 weeks before a scheduled surgery

Interactions

  • Anticoagulant / Antiplatelet drugs
  • Cytochrome P450 1A2 (CYP1A2) substrates

Key References

  • 'Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters.' J Agric Food Chem. 2005
  • 'Pterostilbene inhibits lung cancer through induction of apoptosis.' J Surg Res. 2013
How Vitamin D, Omega-3s, & Exercise May Increase Longevity | Dr. Rhonda Patrick
Essential Insights for Health and Longevity Through Diet and Lifestyle 43:40 0
“The other example is these plant phytochemicals, so these are compounds that are found in a variety of plants, sulforaphane being one in cruciferous plants. There's the resveratrol is probably a very well-known one that's found in the skin of some fruits like grapes and blueberries, pterostilbene, another one found in the skin of blueberries.”

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I don’t own or create any of this data—I just organize it and make it searchable, so always double-check with a real doctor before making any health decisions.