Relaxin
Relaxin is a protein hormone that was originally recognized for its role in pregnancy and childbirth. It is produced in the ovaries and placenta of pregnant females, but it can also be produced in other tissues such as the heart, prostate, and brain. It has a variety of other systemic roles, including cardiovascular, renal, pulmonary, and fibrotic effects.
- Category
- Hormone
- Molecular Formula
- C128H200N46O44
- Mechanism of Action
- Relaxin interacts with specific G-protein coupled receptors, primarily the relaxin family peptide (RXFP) receptors, leading to an increase in the production of second messengers such as cyclic Adenosine Monophosphate (cAMP) and cyclic Guanosine Monophosphate (cGMP). This results in various physiological effects, including vasodilation, angiogenesis, and inhibition of fibrosis.
- Evidence Grade
- C
Other Names
- LGR7
- RLN
- H2 relaxin
- serelaxin
Primary Benefits
- Promotes angiogenesis
- Inhibits fibrosis
- Promotes vasodilation
- Relieves symptoms of acute heart failure
Recommended Dosage
| Typical Dose |
Not applicable for general use |
| Max Dose |
Must be administered under a physician's supervision |
Side Effects
- Headache
- Nausea
- Hypotension
Precautions
- Pregnant women
- People with low blood pressure
- People with kidney problems
Interactions
- Beta blockers
- Diuretics
- ACE inhibitors
Key References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303712/
- https://pubmed.ncbi.nlm.nih.gov/22818947/
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