ssri

No summary available for this substance.

SSRI

Selective Serotonin Reuptake Inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor.

Category
Antidepressant
Molecular Formula
Varies by specific drug
Mechanism of Action
Inhibits the reuptake of serotonin into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor.
Evidence Grade
A

Other Names

  • Selective serotonin reuptake inhibitors
  • serotonin-specific reuptake inhibitor

Primary Benefits

  • Alleviates symptoms of depression
  • Reduces anxiety
  • Helps treat obsessive-compulsive disorder
  • Can aid in post-traumatic stress disorder treatment

Recommended Dosage

Adults Varies based on the specific drug and condition being treated. Always follow the physician's advice.
Children SSRIs are not typically recommended for children. Always follow the physician's advice.

Side Effects

  • Nausea
  • Dry mouth
  • Headache
  • Diarrhea
  • Nervousness, agitation or restlessness
  • Reduced sexual desire or difficulty reaching orgasm
  • Rash
  • Increased sweating

Precautions

  • May increase suicidal thoughts especially in young adults and adolescents
  • Can cause Serotonin Syndrome when combined with other serotonergic drugs
  • Abrupt discontinuation can lead to withdrawal symptoms
  • May interact with other medications

Interactions

  • Other antidepressants
  • Certain pain or headache medicines
  • Certain medicines for psychiatric disorders
  • St. John's wort
  • Certain drugs for obesity

Key References

  • https://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825
  • https://www.nhs.uk/conditions/ssris-selective-serotonin-reuptake-inhibitors/
Improving Science & Restoring Trust in Public Health | Dr. Jay Bhattacharya
Public health discussions on vital topics and practical recommendations. 55:35 0
“90% of the psychoactive drugs like the anti-depressants the SSRIs and related things in the world are prescribed and consumed in the United States.”

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Improving Science & Restoring Trust in Public Health | Dr. Jay Bhattacharya
Public health discussions on vital topics and practical recommendations. 56:20 0
“for the treatment of clinical grade OCD the SSRI have been a tremendous tool they haven't cured OCD in every case but they've been a tremendous tool.”

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How America’s Healthcare System Keeps You Dependent – Calley Means
Health, Environment, Lifestyle: Preventing Disease Through Nutrition and Exercise. 1:29:43 0
“Exercise is a more effective treatment than an SSRI for depression clinically accurate information.”

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The Truth About Microplastics – Dr Rhonda Patrick
Understanding Microplastics and Toxin Exposure in Everyday Health and Environment 1:30:21 0
“there's studies out there now that have compared exercise to like classical ssris right and they're as good if not better at treating depression”

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DO THIS First Thing In The Morning To BOOST YOUR BRAIN & Increase Lifespan! | Dr. Daniel Amen
Boost Brain Health, Optimize Hydration, Nutrition, Mental Wellness, & More 16:03 0
“and thought you were depressed take Prozac and that's what happens in Psychiatry you come to a psychiatrist you tell them your symptoms I'm depressed he gives you a diagnosis with the same name of your you have depression here's an SSRI I mean that's standard it's insane but it's standard”

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Exercise & Nutrition Scientist: The Truth About Exercise On Your Period! Take These 4 Supplements!
Optimizing Women's Health and Performance Through Physiological Understanding 1:03:49 0
“There have been randomized control trials looking at mood and with specifically with regards to depression and anxiety and women who are taking 3 to five grams of creatine will come out of a depressive episode more so than women who are just using an SSRI.”

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Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
Transform health by improving metabolism, hormone regulation, blood sugar control. 1:56:26 0
“there have been other weight loss medications throughout history that you've talked about in the podcast like the fen Fen and then there was another one I think even before that that made people their temperature go up that you talked about so the two these are I used to work on thermal regulation as an undergrad so uh fenfen was eventually banned because it caused some cardiac issues I believe it was a stimulant F Flur me so um sorry it's not Fen Flur me it alone it's a combination of things that's why it's called Fen Fen um and then um dinitrophenol right which was um based on the observation that workers in ammunitions factories were being exposed to this stuff and losing a lot of body fat and weight um it actually made its way into the sports Community it's highly deadly highly deadly just don't even don't even look it up it's highly deadly don't because the moment people start looking it up they started thinking about dabbling the way the internet is now dinitrophenol um and I think it has to do with with um sort of uh processing of the of mitochondria I think…”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 49:02 0
“People that take these things in sufficient doses, meaning the EPAs, are able to get by with much lower dosages of SSRIs for depression relief or, in some cases, to come off their SSRIs completely or avoid going on antidepressant medication.”

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