Uric acid

No summary available for this substance.

Uric Acid

Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen. It is a product of the metabolic breakdown of purine nucleotides, and it is a waste product that is excreted by the kidneys. High levels of uric acid can lead to gout and are associated with other medical conditions including diabetes and the formation of ammonium acid urate kidney stones.

Category
Endogenous Metabolite
Molecular Formula
C5H4N4O3
Mechanism of Action
Produced by the liver and excreted by the kidneys, uric acid helps protect the body from damage by neutralizing free radicals.
Evidence Grade
A

Other Names

  • Urate
  • 2,6,8-Trihydroxypurine

Primary Benefits

  • Antioxidant properties
  • Potential neuroprotective effects

Recommended Dosage

Normal Levels 3.4–7.2 mg/dL for men, 2.4–6.0 mg/dL for women

Side Effects

  • Gout
  • Kidney stones
  • Metabolic syndrome

Precautions

  • Monitor levels in patients with kidney disease
  • Monitor levels in patients with gout

Interactions

  • Alcohol can increase uric acid levels
  • Certain drugs like diuretics can increase uric acid levels

Key References

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197219/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365176/
The Root Cause of Metabolic Dysfunction w/ Dr. Casey Means
Understanding Metabolic Health: Risks, Dysfunction, and Dietary Recommendations 51:49 0
“understand the labs that can give you a hint about your metabolic health so things like the you know apob fasting insulin fasting glucose triglycerides htl cholesterol hscrp an inflammatory marker uric acid vitamin D um I think I said fasting insulin um if you can look at these things every few months and actually be certain that you are like really in the optimal range for a lot of these things and you feel incredible you're probably eating the right diet”

No comments yet.

View all comments (0)
Dr. Robert Lustig: How Sugar & Processed Foods Impact Your Health
Understanding the Complex Relationship Between Nutrition and Metabolic Health 52:03 0
“the glucose has to be phosphorated so you're going to lose an ATP in the process so you're going to go ATP goes to ADP and then that ADP will go to a denzine monophosphate which will then go to im an ocol monophosphate which will then go to Uric acid”

No comments yet.

View all comments (0)
Dr. Robert Lustig: How Sugar & Processed Foods Impact Your Health
Understanding the Complex Relationship Between Nutrition and Metabolic Health 52:29 0
“uric acid can inhibit mitochondrial function and it can also inhibit endothelial nitric oxide synthese which is the enzyme in your vasculature that is your endogenous blood pressure lowerer”

No comments yet.

View all comments (0)
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
Transform health by improving metabolism, hormone regulation, blood sugar control. 1:12:28 0
“there are so many other tests that I talked about in my book and that you've talked about on your podcast apob uric acid fasting insulin hom IR hscrp liver function tests ggt all these other tests that are great that can really tell us more about mitochondrial dysfunction oxidative stress chronic inflammation but the ones I'm mentioning are the ones that you will not have to fight with your doctor about like the the the everything I just mentioned like the doctor should order on an annual physical and it's really about us learning to act like read the Tea Leaves of what they're saying and not look at them in this algorithmic way but like how together if they're creeping up or if many of them are a little bit high like we need to focus all of our energy on improving mitochondrial capacity basically and and bring those numbers down which we can do very very quickly once you start getting the mitochondria moving through more of those substrates a lot of them will just naturally come down.”

No comments yet.

View all comments (0)