Vascepa

No summary available for this substance.

Vascepa

Vascepa, also known as Icosapent Ethyl, is a prescription medication used to reduce triglyceride levels in adults with severe hypertriglyceridemia. It is a purified form of omega-3 fatty acid obtained from fish oil and works by decreasing the amount of triglycerides produced by the body.

Category
Prescription medication
Molecular Formula
C22H34O2
Mechanism of Action
Vascepa works by reducing the hepatic synthesis and secretion of triglycerides in the bloodstream.
Evidence Grade
A

Other Names

  • Icosapent Ethyl
  • Amarin

Primary Benefits

  • Reduces triglyceride levels
  • May decrease the risk of cardiovascular disease

Recommended Dosage

Adults 2 grams twice daily with meals

Side Effects

  • Joint pain
  • Sore throat
  • Allergic reactions

Precautions

  • Avoid if allergic to fish or shellfish
  • May increase LDL cholesterol levels
  • Use cautiously in patients with hepatic impairment

Interactions

  • Anticoagulant drugs
  • Antiplatelet drugs

Key References

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589309/
  • https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/vascepa-icosapent-ethyl-capsules
Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 12:57 0
“the FDA in their package insert for Lovaza and Vascepa they say does not cause clinically significant bleeding.”

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Dr. Bill Harris on the Omega-3 Index: Increasing Omega-3 to Promote Longevity & Transform Health
Understanding Omega-3 Impact: Health Benefits Through Diet and Research 13:19 0
“Lovaza is the EPA plus DHA ethyl ester, Vascepa is an EPA-only ethylester.”

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Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Huberman Lab Podcast #70
Optimizing Health and Longevity Through Nutrients and Lifestyle Choices 40:00 0
“One of the major prescription omega-3s out there is, both of them actually, Lovaza, which is a mixture of DHA and EPA, as well as Vascepa, which is a highly purified EPA.”

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