Essential habits for long-lasting health and vitality without extremes or shortcuts

Exercise 0:00 0
“having a very high VO2 max, being incredibly strong, that's going to do more for your lifespan and health span than any piece of technology or biohacking or manipulation of gut biome or any other thing that people are talking about.”

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Nutrition 5:07 0
“there's basically three ways to go about reducing intake so if you're over nourished which is the kind of way I describe people that have too much body fat especially in places where you don't want it right so it's not really the subcutaneous fat we're worried about it's the visceral fat it's the intramuscular fat it's the peripancreatic fat perinephric fat all of”

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Body weight 5:31 0
“those things that are metabolically destructive so not the Cosmetic fat that actually has no metabolic um consequence so let's assume you established that a person needs to you know me I need to lose I need to reduce energy intake I can do it by calorie counting or tracking my macros I can do it by dietary restriction by sort of identifying things within the diet that I don't want to eat and limiting them or I can do it via time restriction just narrowing the window down in which I eat”

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Nutrition 6:59 0
“one of my friends Alex mentioned to me the other day that most people have a bucket of perhaps between 5 and 10 meals that they typically eat and he said that one of the longest levers when it comes to altering your diet is to just look at those five to ten meals even forget about everything else it's like what do you eat the most you probably have for me it's like full recipes that I go back to very consistently okay what's that constituted of and how can you just Tinker with that a little bit for it to be closer to what your goals are”

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Purpose 12:06 0
“what do you want to be true at the end of your life and the the framework that I use for that is called the marginal decade so the marginal decade is the last decade of your life everyone will have a marginal decade and that's not a pleasant thought for many of us to think about right I don't love thinking about the fact that I'm going to have a marginal decade but I will”

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Exercise 15:29 0
“so for example walking a golden retriever at the age of 35 you don't even have to think about it but if you actually look at the force that's in that leash and the amount of balance and strength and lower leg variability you need to not fall over when that's happening by the time you're in your 70s that's going to be very difficult so you have to build up an enormous Reserve in those capacities today to cope with and anticipate the inevitable decline that's going to come in all of those”

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Metabolic health 16:48 0
“there's a reason that you know having type 2 diabetes having atherosclerosis is an enormous cause of impotence”

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Sun protection 18:09 0
“Peter my objective right now is not to get a sunburn... you're going to avoid the sun altogether if you need to be in the sun you're going to wear long sleeves and a hat and you're going to wear sunscreen”

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Exercise 20:45 0
“how can we understand for example the benefits of exercise when we look at the cellular level when we understand them you know when we look at proteomic metabolomic changes of exercise”

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Nutrition 22:31 0
“it's very tempting to just focus on your favorite thing like there was a point in time where virtually all of my attention was focused on nutrition”

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Nutrition 23:37 0
“once you get beyond the real fundamentals of energy balance and protein intake I honestly think a lot of people are spending too much time thinking about the finer details of it”

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Nutrition 24:24 0
“the belief system that I once had and that I think many others have that you know this exact ratio of omega-6 to omega-3 is what's essential if that's true it's not based on any evidence as of this time”

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Nutrition 26:58 0
“I'm someone who probably takes a lot of effort to consume 1.8 to 2 grams of protein per kilogram of body weight and that's going to be spread out over three to four meals but there's probably still 14 hours a day when I'm not eating anything and during that period of time those amino acid levels are going to be really low”

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Nutrition 27:42 0
“someone that's done intermittent fasting I sat down with David Sinclair four and a half years ago I think in his office at Harvard uh and you know when David first came onto the scene which was the first time I'd really really heard intermittent fasting as being pushed as a longevity lever”

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Nutrition 29:05 0
“the biggest drawback of that final strategy which again is a viable strategy but the biggest drawback of it in my opinion is the the reduction in protein intake”

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Nutrition 31:02 0
“so what you don't want to do is waste for lack of a better word your amino acids down a gluconeogenic pathway where they're basically being used as glucose substrate”

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Nutrition 31:50 0
“so you're saying for most people it seems like roughly a sweet spot is 25 to 50 grams per serving exactly right”

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Substances 33:40 0
“Aspartame which is the original kind of the OG sweetener uh everybody loves to demonize aspartame or NutraSweet but the reality of it is if there is toxicity to it it's probably impossible to measure at regular doses.”

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Substances 35:32 0
“There was a recent study published that looked at uh one particular sweetener erythritol and um it was a pretty poorly done study um but look it asked some interesting questions right which is you know is a metabolite of this potentially atherogenic.”

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Substances 36:15 0
“My personal favorite of all of them is something called allulose. Allulose is it's basically natural it is an enantiomer of fructose meaning it's a molecule that's almost identical to fructose with one very minor structural change.”

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Disease prevention 39:08 0
“there were basically about seven or eight things that are a threat to your length of life and quality of life we've talked about them already right so cardiovascular disease cerebrovascular disease cancer neurodegenerative disease Orthopedic injury emotional distress misery like all those things right”

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Disease prevention 39:29 0
“so how do we know how you're stacking up on all of those things what are the inputs to do them so yeah blood tests family history selective genetic testing colonoscopy MRI liquid biopsy VO2 max Test Zone 2 test dexa scan I mean the list is long and I I think in our Matrix we have over 40 things that go into that or over 40 inputs that go into our risk assessment”

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Disease prevention 40:16 0
“if an individual shows up and they have a significant family history of cardiovascular disease well look a CT angiogram is going to be very important and a blood test that's measuring LP little a lipids and APO B is essential because you have to know which you know which of these things is responsible for that”

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Disease prevention 40:49 0
“blood pressure is one of the biggest risk factors for Alzheimer's disease and cardiovascular disease”

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Exercise 44:58 0
“exercise is is a big one aerobic exercise is an enormous way to lower blood pressure”

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Nutrition 45:05 0
“weight loss is going to be mostly driven by nutrition”

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Sleep 45:11 0
“two of the most obvious things that show up when I'm not well slept is you know higher blood glucose and higher blood pressure”

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Exercise 50:24 0
“to have a high number you must be exercising a lot and we know the benefits of exercising a lot”

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Exercise 50:40 0
“exercise has more benefit than probably any other single intervention we can do”

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Exercise 51:30 0
“what is the best protocol that you have found for improving VO2 max in terms of training”

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Exercise 52:13 0
“the base widening training is what we call zone two training”

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Exercise 52:32 0
“I do my zone two on a bike, on a trainer indoors”

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Exercise 53:58 0
“VO2 max training is maximized between three and eight minute intervals”

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Exercise 55:34 0
“four times a week doing those lesser zone two sets, how long on zone two? uh 45 to 60 minutes a session.”

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Exercise 55:46 0
“I'm basically doing four to five weeks of cardio training a week which is, you know, depends who you ask like first by my historical standards that's very very low obviously for some people that would still be considered a lot.”

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Exercise 56:47 0
“strength is probably the easier one for people to understand, you know that's basically your ability to generate force.”

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Exercise 1:01:16 0
“nobody understands what balance training is yeah no one understands what what are the principles behind this no one's ever thought about stability training before uh how do you integrate it into your workouts and then also what does a dedicated session look like”

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Exercise 1:05:04 0
“my introduction to stability only came the hard way it's not like I was born out of the womb realizing this was an important thing I mean I had to go through horrible injuries to finally arrive at this place where I said you know I'm tired of being in pain I'm tired of the fact that my elbow hurts when I do pull-ups and you know oh like half the time I deadlift or squat my back hurts the next day like I was just kind of tired of that”

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Exercise 1:07:05 0
“we basically just started piece by piece rebuilding my movements and by the way that meant spending a year not doing pull-ups and not dead lifting as I re-learned how to how to align my body again”

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Exercise 1:07:42 0
“a lot of what DNS is based on is the idea that up until we were about two years old we all moved almost perfectly”

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Exercise 1:10:12 0
“one of the things I'm working on with Kyler is Soleus strengthening to actually counteract that movement”

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Exercise 1:12:33 0
“the top five exercises were step UPS or step up variations it's like Step Up, cross body step up, lateral step up, something something something and then maybe hex bar deadlift was in the sort of upper middle, deadlift another one and then you get down toward like glute Bridge Kickback and it's at 25 and I think it's 95 on this particular scale of this number would Step Up.”

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Toxin exposure 1:14:35 0
“I don't think the industry is standardized enough to be sure that what is being inhaled is sufficiently clean, maybe it is maybe some companies are better than others I mean we could talk about that all day long but I'm not personally willing to put my trust in that in that market in that infrastructure in those companies whatsoever.”

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Substances 1:17:57 0
“I went sober for six months really loved it, most to do with the lifestyle changes, cognitive improvements, what it meant in terms of habit in terms of consistency energy, money, time all that stuff came back to drinking didn't like it went back to sober for another six months came back to drinking for a couple of months didn't like it did a thousand days sober.”

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Sleep 1:18:51 0
“with the rise of sleep trackers I think you really have some objective data on the downside and I don't think anybody who's worn a whoop who doesn't look at their heart rate variability pre and post alcohol consumption or the fragmentation of their sleep is not saying what the hell it's insane why is it such an impact.”

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Genetics 1:21:33 0
“the first thing I think everybody needs to know, you're talking about from a personal risk standpoint or just understanding the disease personal risk okay yeah so the first thing I I you know we want to know from all of our patients is tell us your family history right that you know there is a genetic component to this disease so let's understand what your susceptibility is.”

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Genetics 1:23:35 0
“Chris learned that he has two copies of the APO E4 Gene and the APO E4 Gene is the most common genetic uh you know the most common Gene responsible for Alzheimer's disease but not but it's not early it's not early onset right it's a late onset predisposition.”

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Genetics 1:23:53 0
“the early onset ones are um called app psen1 psen2”

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Exercise 1:25:06 0
“it might factor into how we prescribe exercise”

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Exercise 1:26:24 0
“exercise is one of the longest if not maybe the longest I think it is that you're talking about”

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Sleep 1:29:12 0
“sleeping well”

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Exercise 1:29:15 0
“be strong as hell have a high VO2 max”

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Disease prevention 1:29:35 0
“heart disease is the biggest killer on the planet at the moment”

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Disease prevention 1:31:42 0
“smoking high blood pressure and high APO B are the main drivers of atherosclerosis”

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Exercise 1:34:01 0
“exercise not surprising, and probably more so the benefit on cardio here you're probably going to see more of a the data would certainly suggest that cardio is the more important exercise of the two”

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Sleep 1:34:29 0
“poor sleep has devastating impact on the heart probably through sympathetic overtone, hypercortisolemia things like that”

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Stress management 1:34:40 0
“stress becomes another thing that really matters it's kind of again it's one of these sort of fuzzy terms that kind of seems like oh yeah yeah stress I'm sure but but I think the data are very clear that high levels of cortisol are really damaging to coronary arteries”

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Nutrition 1:34:56 0
“nutrition kind of factors in probably to the pharmacologic strategy”

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Nutrition 1:35:21 0
“if you went on like a 10% fat diet, you would probably drop your lipid levels to you know very healthy levels.”

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Nutrition 1:37:40 0
“I'm not going to compromise sleep or exercise because I know that those two things factor far more into my productivity, my cognitive capacity, and my mood truthfully.”

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Purpose 1:38:35 0
“I don't really know what motivation means, I, at least for me personally, I'm sure for some people that word has meaning, for me kind of purpose is the thing that matters.”

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Exercise 1:40:45 0
“just don't feel right during the warm-up like it just doesn't feel good and I'll say you know what I'm not going to abort the deadlift today I'm gonna go and do some safer exercises where the stakes are a lot lower and if I make a mistake I'm not going to get punished for it the way I'm going to punished if I'm doing deadlifts and I don't have my form just right.”

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Purpose 1:41:06 0
“you've got to be able to play the long game I think and I I don't know what to tell somebody to get them there other than anchoring them to the marginal decade because if you know what you're training for then of course you wouldn't take that risk right.”

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Social connection 1:45:52 0
“I mean we are evolutionarily so wired to be social creatures and that doesn't like I'm an introvert but which means like I don't like really being around that many people and I certainly don't like being around strangers but I would die if I was alone.”

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Social connection 1:46:45 0
“we certainly know at the extreme end of the spectrum that loneliness is an enormous predisposing factor for suicide”

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Mental health 1:49:02 0
“I do think that there are biochemical ways that impact probably through stress hormones probably through greater activation of sympathetic you know an imbalance between sympathetic and parasympathetic flow I think those things absolutely do impact our immune function our cardiovascular function all these things”

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Exercise 1:51:15 0
“call it 12 to 14 hours a week of exercise is very important for me”

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Exercise 1:52:22 0
“I like rucking that's something we didn't really talk about I don't really lump that into my exercise bucket of time though it is obviously a great type of exercise but because of the way that I'm doing it which is I'm not taking any Electronics with me and I'm not multitasking when I do it it really is just as much about my brain as it is my body.”

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Mental health 1:52:40 0
“it really is just as much about my brain as it is my body.”

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Exercise 1:57:07 0
“and that's why by the way I think the Step Up is an amazing exercise the Step Up is the movement that tells you you can get up off the floor”

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Exercise 1:57:17 0
“I've been playing around with a Vitruvian at home which is kind of like a tonal, it's like magnetic Drive training thing and they sent me one two or three months ago this thing's so much fun it's so cool.”

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Exercise 1:58:10 0
“it can do eccentric only training yeah and it goes up to 440 pounds of of weight and doing step ups with that or doing my favorite movement with that is a front foot elevated split squat so putting up onto that handles in either hand”

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Circadian rhythm 1:23:12 0
“one of the prescriptions that you've got is you have like a 15 to 30 minute window for sleeping for wake and like try and lock that in”

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Hydration 2:04:08 0
“if you drink the wrong amount of water on the night time do you have to get up and go to the bathroom in the middle of the night like [ __ ] yeah like right dude”

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Exercise and Health

The paramount importance of exercise is expressed through a focus on maintaining a high VO2 max and strength, proving essential not just for extended lifespan but for health spans as well. Regular exercise that involves both strength and cardiovascular training is recommended. Specific exercises like zone two cardio and interval training to improve VO2 max are highlighted, suggesting a schedule of around 45 to 60 minutes sessions, four times a week, for effective results.

Nutrition and Weight Management

Key discussions about nutrition emphasize the reduction of unhealthy fat types, specifically visceral and intramuscular fats, primarily through different methods such as calorie counting, dietary restrictions, and time-restricted eating. The narrative consistently highlights the need for a balanced diet and focusing on frequently consumed meals to improve overall diet quality. Noteworthy is the focus on maintaining energy balance and adequate protein intake, with a suggested intake of 1.8 to 2 grams per kilogram of body weight, distributed across meals throughout the day.

Understanding and Managing Chronic Conditions

The series sheds light on metabolic health with a focus on conditions like Type 2 diabetes and their impact on overall health, including areas such as sexual health. Proteomic and metabolomic changes due to exercise also factor in, showcasing the cellular benefits of regular physical activity.

Sun Protection and Substance Use

Simple yet effective strategies for sun protection include avoiding sun exposure and adopting protective clothing and sunscreen. Discussions about substances like artificial sweeteners and alcohol highlight considerations for usage based on safety and health impacts, noting personal experiences with sobriety and the noticeable benefits it had on lifestyle and cognitive functions.

Disease Prevention Strategies

Preventative measures against diseases involve regular screenings and personalized assessments based on family history and genetic testing, particularly for cardiovascular diseases. The importance of monitoring key health markers such as blood pressure is underlined due to its link with diseases like Alzheimer’s.

Mental and Social Health

The connections between mental health, stress management, and physical health are explored, particularly pointing out how biochemical processes can affect bodily functions. Social connections are also emphasized as vital for mental well-being, with isolation described as a considerable risk factor for conditions like depression and suicide.

In summary, the narratives presented encapsulate a comprehensive approach towards managing one’s health through practical lifestyle adjustments, regular physical activity, mindful nutrition, and active prevention and management of potential health issues.